Anti-CCK4 antibody (ab117412)
Key features and details
- Rabbit polyclonal to CCK4
- Suitable for: WB
- Reacts with: Human
- Isotype: IgG
Overview
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Product name
Anti-CCK4 antibody
See all CCK4 primary antibodies -
Description
Rabbit polyclonal to CCK4 -
Host species
Rabbit -
Tested applications
Suitable for: WBmore details -
Species reactivity
Reacts with: Human -
Immunogen
Purified Human CCK4 protein, emulsified in complete adjuvant.
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General notes
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
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Properties
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Form
Liquid -
Storage instructions
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid repeated freeze / thaw cycles. -
Storage buffer
Constituent: Proprietary component -
Concentration information loading...
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Purity
Immunogen affinity purified -
Purification notes
The anti-serum was pre-cleared for tag protein and then affinity purified on immobilized PTK7 affinity chromatography. -
Clonality
Polyclonal -
Isotype
IgG -
Research areas
Associated products
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Compatible Secondaries
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Isotype control
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Recombinant Protein
Applications
The Abpromise guarantee
Our Abpromise guarantee covers the use of ab117412 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Application | Abreviews | Notes |
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WB | (3) |
1/500. Detects a band of approximately 133 kDa (predicted molecular weight: 93 kDa).
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Notes |
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WB
1/500. Detects a band of approximately 133 kDa (predicted molecular weight: 93 kDa). |
Target
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Function
Inactive tyrosine kinase involved in Wnt signaling pathway. Component of both the non-canonical (also known as the Wnt/planar cell polarity signaling) and the canonical Wnt signaling pathway. Functions in cell adhesion, cell migration, cell polarity, proliferation, actin cytoskeleton reorganization and apoptosis. Has a role in embryogenesis, epithelial tissue organization and angiogenesis. -
Tissue specificity
Highly expressed in lung, liver, pancreas, kidney, placenta and melanocytes. Weakly expressed in thyroid gland, ovary, brain, heart and skeletal muscle. Also expressed in erythroleukemia cells. But not expressed in colon. -
Sequence similarities
Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily.
Contains 7 Ig-like C2-type (immunoglobulin-like) domains.
Contains 1 protein kinase domain. -
Domain
The protein kinase domain is predicted to be catalytically inactive. -
Post-translational
modificationsMMP14 cleaves PTK7 between Pro-621 and Leu-622 generating an N-terminal soluble (70 kDa) fragment and a membrane C-terminal (50 kDa) fragment. Proteolysis by MMP14 regulates PTK7 function in non-canonical Wnt signaling pathway. -
Cellular localization
Membrane. Cell junction. Colocalizes with MMP14 at cell junctions. Also localizes at the leading edge of migrating cells. - Information by UniProt
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Database links
- Entrez Gene: 5754 Human
- Omim: 601890 Human
- SwissProt: Q13308 Human
- Unigene: 90572 Human
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Alternative names
- 8430404F20Rik antibody
- CCK 4 antibody
- CCK-4 antibody
see all
Images
Protocols
Datasheets and documents
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Datasheet download
References (0)
ab117412 has not yet been referenced specifically in any publications.