Overview

  • Product nameAnti-CCKAR antibody
    See all CCKAR primary antibodies
  • Description
    Rabbit polyclonal to CCKAR
  • Tested applicationsSuitable for: IHC-Pmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Synthetic peptide, corresponding to the 3rd cytoplasmic domain of Human CCKAR.

  • Positive control
    • Human adrenal and prostate tissues.

Properties

Applications

Our Abpromise guarantee covers the use of ab115287 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P Use a concentration of 10 µg/ml. requires pre-treatment with Proteinase K.

Target

  • RelevanceThe cholecystokinin (CCK) family of peptide hormones have been implicated in numerous important physiologic events. These appear to be mediated through 2 general classes of receptors, A (CCKAR)and B (CCKBR), based on their binding affinities for CCK/gastrin family peptides. Through binding to class A receptors, CCK is a major physiologic mediator of gallbladder contraction and pancreatic enzyme secretion. It appears to play a role in slowing gastric emptying, relaxation of the sphincter of Oddi, and potentiation of insulin secretion. Further, it has been implicated as a mediator of pancreatic growth and tumorigenesis. Class A receptors have also been described in the anterior pituitary, myenteric plexus, and regions of the central nervous system, where they have been implicated in the pathogenesis of feeding disorders, Parkinson disease, schizophrenia, and drug addiction.
  • Cellular localizationIntegral membrane protein
  • Database links
  • Alternative names
    • CCK A antibody
    • CCK A receptor antibody
    • CCK AR antibody
    • CCK-A receptor antibody
    • CCK1 R antibody
    • CCK1-R antibody
    • CCK1R antibody
    • CCKA antibody
    • CCKA receptor antibody
    • CCKR Type A antibody
    • CCKRA antibody
    • Cholecystokinin 1 receptor antibody
    • Cholecystokinin A receptor antibody
    • Cholecystokinin receptor type A antibody
    • Cholecystokinin type A receptor antibody
    see all

Anti-CCKAR antibody images

  • ab115287, at 10µg/ml, staining CCKAR in Formalin-fixed, Paraffin-embedded Human Prostate tissue by Immunohistochemistry.
  • ab115287, at 10µg/ml, staining CCKAR in Formalin-fixed, Paraffin-embedded Human Adrenal tissue by Immunohistochemistry.

References for Anti-CCKAR antibody (ab115287)

ab115287 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"