Overview

  • Product nameAnti-CCKAR antibody
    See all CCKAR primary antibodies
  • Description
    Rabbit polyclonal to CCKAR
  • Tested applicationsSuitable for: ICC, IHC-P, WBmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Dog
  • Immunogen

    Synthetic peptide:

    TGASLSRFSYSHMSASVPPQ

    conjugated to KLH, corresponding to amino acids 409-428 of Human CCKAR

  • Positive control
    • HEK293 cells that have been transfected to express CCK1.

Properties

Applications

Our Abpromise guarantee covers the use of ab28627 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
ICC 1/1000.
IHC-P 1/500.
WB 1/1000. Detects a band of approximately 80-90 kDa.

Target

  • RelevanceThe cholecystokinin (CCK) family of peptide hormones have been implicated in numerous important physiologic events. These appear to be mediated through 2 general classes of receptors, A (CCKAR)and B (CCKBR), based on their binding affinities for CCK/gastrin family peptides. Through binding to class A receptors, CCK is a major physiologic mediator of gallbladder contraction and pancreatic enzyme secretion. It appears to play a role in slowing gastric emptying, relaxation of the sphincter of Oddi, and potentiation of insulin secretion. Further, it has been implicated as a mediator of pancreatic growth and tumorigenesis. Class A receptors have also been described in the anterior pituitary, myenteric plexus, and regions of the central nervous system, where they have been implicated in the pathogenesis of feeding disorders, Parkinson disease, schizophrenia, and drug addiction.
  • Cellular localizationIntegral membrane protein
  • Database links
  • Alternative names
    • CCK A antibody
    • CCK A receptor antibody
    • CCK AR antibody
    • CCK-A receptor antibody
    • CCK1 R antibody
    • CCK1-R antibody
    • CCK1R antibody
    • CCKA antibody
    • CCKA receptor antibody
    • CCKR Type A antibody
    • CCKRA antibody
    • Cholecystokinin 1 receptor antibody
    • Cholecystokinin A receptor antibody
    • Cholecystokinin receptor type A antibody
    • Cholecystokinin type A receptor antibody
    see all

Anti-CCKAR antibody images

  • ab28627 staining Human CCKAR in Human gastric mucosa by immunohistochemistry using paraffin embedded tissue.

References for Anti-CCKAR antibody (ab28627)

This product has been referenced in:
  • Gonzalez-Coto AF  et al. Expression of cholecystokinin, gastrin, and their receptors in the mouse cornea. Invest Ophthalmol Vis Sci 55:1965-75 (2014). Mouse . Read more (PubMed: 24576871) »

See 1 Publication for this product

Product Wall

Thank you for your enquiry. I am sorry we do not supply this peptide as one of our products. The sequence of the immunogen used is TGASLSRFSYSHMSASVPPQ. I hope this has helped. Please do get back to me if you have any more queries. With thanks.

Read More

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"