Recombinant
RabMAb

Anti-CCL14 antibody [EP7727] (ab154174)

Overview

  • Product name
    Anti-CCL14 antibody [EP7727]
    See all CCL14 primary antibodies
  • Description
    Rabbit monoclonal [EP7727] to CCL14
  • Tested applications
    Suitable for: WBmore details
    Unsuitable for: ICC/IF,IHC-P or IP
  • Species reactivity
    Reacts with: Recombinant fragment
    Predicted to work with: Human
  • Immunogen

    Synthetic peptide corresponding to residues in Human CCL14 (UniProt: Q16627).

  • Positive control
    • Human CCL14 recombinant protein.
  • General notes

    This product is a recombinant rabbit monoclonal antibody.

    Mouse, Rat: We have preliminary internal testing data to indicate this antibody may not react with these species. Please contact us for more information.

    Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMab® patents

Properties

Applications

Our Abpromise guarantee covers the use of ab154174 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/1000 - 1/10000. Predicted molecular weight: 10 kDa.
  • Application notes
    Is unsuitable for ICC/IF,IHC-P or IP.
  • Target

    • Function
      Has weak activities on human monocytes and acts via receptors that also recognize MIP-1 alpha. It induced intracellular Ca(2+) changes and enzyme release, but no chemotaxis, at concentrations of 100-1,000 nM, and was inactive on T-lymphocytes, neutrophils, and eosinophil leukocytes. Enhances the proliferation of CD34 myeloid progenitor cells. The processed form HCC-1(9-74) is a chemotactic factor that attracts monocytes eosinophils, and T-cells and is a ligand for CCR1, CCR3 and CCR5.
    • Tissue specificity
      Expressed constitutively in several normal tissues: spleen, liver, skeletal and heart muscle, gut, and bone marrow, present at high concentrations (1-80 nM) in plasma.
    • Sequence similarities
      Belongs to the intercrine beta (chemokine CC) family.
    • Post-translational
      modifications
      The N-terminal processed forms HCC-1(3-74), HCC-1(4-74) and HCC-1(9-74) are produced in small amounts by proteolytic cleavage after secretion in blood.
      HCC-1(1-74), but not HCC-1(3-74) and HCC-1(4-74), is partially O-glycosylated; the O-linked glycan consists of one Gal-GalNAc disaccharide, further modified by two N-acetylneuraminic acids.
    • Cellular localization
      Secreted.
    • Information by UniProt
    • Database links
    • Alternative names
      • CC-1 antibody
      • CC-3 antibody
      • CCL14 antibody
      • CCL14_HUMAN antibody
      • chemokine (C-C motif) ligand 14 antibody
      • Chemokine CC-1/CC-3 antibody
      • chemokine CC1 antibody
      • chemokine CC3 antibody
      • chemokine HCC1 antibody
      • chemokine HCC3 antibody
      • CKb1 antibody
      • HCC-1(1-74) antibody
      • HCC-1(9-74) antibody
      • HCC-1/HCC-3 antibody
      • HCC-3 antibody
      • HCC1 antibody
      • HEMOFILTRATE CC CHEMOKINE 1 antibody
      • MCIF antibody
      • NCC-2 antibody
      • NCC2 antibody
      • new CC chemokine 2 antibody
      • SCYA14 antibody
      • SCYL2 antibody
      • small inducible cytokine subfamily A (Cys-Cys), member 14 antibody
      • Small-inducible cytokine A14 antibody
      • SY14 antibody
      see all

    Images

    • Anti-CCL14 antibody [EP7727] (ab154174) at 1/1000 dilution + Human CCL14 recombinant protein at 0.05 µg

      Secondary
      HRP labelled goat anti-rabbit at 1/2000 dilution

      Predicted band size : 10 kDa

    References

    ab154174 has not yet been referenced specifically in any publications.

    Customer reviews and Q&As

    There are currently no Customer reviews or Questions for ab154174.
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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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