Human Predicted to work with:
Mouse, Rat, Cow, Orangutan
Recombinant fragment: LVAENGKKDQ VAQMADIVDI SDEISPSVDD LALSIYPPMC HLTVRINSAK LVSVLKKALE ITKASHVTPQ PEDSWIPLLI NAIDHCMNRI KELTQSELEL , corresponding to amino acids 261-360 of human CCNDBP1 (NP_036274) with a 26 kDa tag
FunctionMay negatively regulate cell cycle progression. May act at least in part via inhibition of the cyclin-D1/CDK4 complex, thereby preventing phosphorylation of RB1 and blocking E2F-dependent transcription.
Tissue specificityUbiquitously expressed. Expression is down-regulated in a variety of tumor types including breast, colon, prostate and rectal tumors, and is up-regulated in certain hepatic carcinomas.
Sequence similaritiesBelongs to the CCNDBP1 family.
Developmental stageExpression may increase during differentiation.