Overview

  • Product nameAnti-CCNL1 antibody
    See all CCNL1 primary antibodies
  • Description
    Rabbit polyclonal to CCNL1
  • Tested applicationsSuitable for: WB, IP, ELISA, IHC-Pmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Mouse, Rat, Chicken, Dog
  • Immunogen

    Synthetic peptide: KLKAKGLNPD GTPALSTLGG FSPASKPSSP REVKAEEKSP ISINVKTVKK EPEDRQ, corresponding to amino acids 314-369 of Human Cyclin L1a

  • Positive control
    • Human thymus tissue

Properties

Applications

Our Abpromise guarantee covers the use of ab118957 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/2000 - 1/5000. Predicted molecular weight: 60 kDa.
IP Use at an assay dependent concentration.
ELISA 1/5000 - 1/25000.
IHC-P Use a concentration of 10 - 20 µg/ml. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.

Target

  • FunctionTranscriptional regulator which participates in regulating the pre-mRNA splicing process. Seems to be involved in the regulation of RNA polymerase II (pol II). Functions in association with cyclin-dependent kinases (CDKs) and has a role in the second step of splicing. May be a candidate proto-oncogene in head and neck squamous cell carcinomas (HNSCC). Inhibited by the CDK-specific inhibitor p21.
  • Tissue specificityUbiquitous with higher level in thymus. Overexpression in primary tumors of head and neck squamous cell carcinomas (HNSCC).
  • Sequence similaritiesBelongs to the cyclin family. Cyclin L subfamily.
  • DomainContains a RS region (arginine-serine dipeptide repeat) within the C-terminal domain which is the hallmark of the SR family of splicing factors. This region probably plays a role in protein-protein interactions.
  • Cellular localizationNucleus speckle. More specifically found in nuclear intrachromatin granules clusters (IGC), also called nuclear speckles, which are storage compartments for nuclear proteins involved in mRNA processing.
  • Information by UniProt
  • Database links
  • Alternative names
    • Ania 6a antibody
    • CCNL1 antibody
    • CCNL1_HUMAN antibody
    • Cyclin L antibody
    • Cyclin L gamma antibody
    • Cyclin L1 antibody
    • Cyclin-L antibody
    • Cyclin-L1 antibody
    see all

Anti-CCNL1 antibody images

  • ab118957 at 20µg/ml staining paraffin embedded formalin fixed CCNL1 in Human thymus tissue by immunohistochemistry. Following primary incubation slides were incubated with biotinylated goat anti-rabbit IgG secondary antibody, alkaline phosphatase-streptavidin and chromogen.

References for Anti-CCNL1 antibody (ab118957)

ab118957 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"