Overview

  • Product name
  • Description
    Rabbit polyclonal to CCNL1
  • Tested applications
    Suitable for: WB, ELISAmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Mouse, Rat, Cow
  • Immunogen

    A region within a synthetic peptide: TGGILIGDRL YSEVSLTIDH SLIPEERLSP TPSMQDGLDL PSETDLRILG, corresponding to N terminal amino acids 37-86 of Human CCNL1

  • Positive control
    • HepG2 cell lysate

Properties

Applications

Our Abpromise guarantee covers the use of ab26253 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 2.5 µg/ml. Detects a band of approximately 57 kDa (predicted molecular weight: 60 kDa). Good results were obtained when blocked with 5% non-fat dry milk in 0.05% PBS-T.
ELISA 1/62500.

Target

  • Function
    Transcriptional regulator which participates in regulating the pre-mRNA splicing process. Seems to be involved in the regulation of RNA polymerase II (pol II). Functions in association with cyclin-dependent kinases (CDKs) and has a role in the second step of splicing. May be a candidate proto-oncogene in head and neck squamous cell carcinomas (HNSCC). Inhibited by the CDK-specific inhibitor p21.
  • Tissue specificity
    Ubiquitous with higher level in thymus. Overexpression in primary tumors of head and neck squamous cell carcinomas (HNSCC).
  • Sequence similarities
    Belongs to the cyclin family. Cyclin L subfamily.
  • Domain
    Contains a RS region (arginine-serine dipeptide repeat) within the C-terminal domain which is the hallmark of the SR family of splicing factors. This region probably plays a role in protein-protein interactions.
  • Cellular localization
    Nucleus speckle. More specifically found in nuclear intrachromatin granules clusters (IGC), also called nuclear speckles, which are storage compartments for nuclear proteins involved in mRNA processing.
  • Information by UniProt
  • Database links
  • Alternative names
    • Ania 6a antibody
    • CCNL1 antibody
    • CCNL1_HUMAN antibody
    • Cyclin L antibody
    • Cyclin L gamma antibody
    • Cyclin L1 antibody
    • Cyclin-L antibody
    • Cyclin-L1 antibody
    see all

Images

References

ab26253 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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