• Product nameAnti-CCNL1 antibody
    See all CCNL1 primary antibodies
  • Description
    Rabbit polyclonal to CCNL1
  • Specificityab53045 detects endogenous levels of total CCNL1 protein.
  • Tested applicationsSuitable for: WB, IHC-P, ELISAmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Mouse, Rat
  • Immunogen

    A synthetic peptide derived from human CCNL1.

  • Positive control
    • Human breast carcinoma tissue and HepG2 cell extracts.



Our Abpromise guarantee covers the use of ab53045 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/500 - 1/1000. Detects a band of approximately 113 kDa (predicted molecular weight: 60 kDa).
IHC-P Use at an assay dependent concentration.
ELISA 1/10000.


  • FunctionTranscriptional regulator which participates in regulating the pre-mRNA splicing process. Seems to be involved in the regulation of RNA polymerase II (pol II). Functions in association with cyclin-dependent kinases (CDKs) and has a role in the second step of splicing. May be a candidate proto-oncogene in head and neck squamous cell carcinomas (HNSCC). Inhibited by the CDK-specific inhibitor p21.
  • Tissue specificityUbiquitous with higher level in thymus. Overexpression in primary tumors of head and neck squamous cell carcinomas (HNSCC).
  • Sequence similaritiesBelongs to the cyclin family. Cyclin L subfamily.
  • DomainContains a RS region (arginine-serine dipeptide repeat) within the C-terminal domain which is the hallmark of the SR family of splicing factors. This region probably plays a role in protein-protein interactions.
  • Cellular localizationNucleus speckle. More specifically found in nuclear intrachromatin granules clusters (IGC), also called nuclear speckles, which are storage compartments for nuclear proteins involved in mRNA processing.
  • Information by UniProt
  • Database links
  • Alternative names
    • Ania 6a antibody
    • CCNL1 antibody
    • CCNL1_HUMAN antibody
    • Cyclin L antibody
    • Cyclin L gamma antibody
    • Cyclin L1 antibody
    • Cyclin-L antibody
    • Cyclin-L1 antibody
    see all

Anti-CCNL1 antibody images

  • All lanes : Anti-CCNL1 antibody (ab53045) at 1/500 dilution

    Lane 1 : HepG2 cell extract
    Lane 2 : HepG2 cell extract with immunising peptide

    Predicted band size : 60 kDa
    Observed band size : 113 kDa (why is the actual band size different from the predicted?)
  • ab53045 at 1/50-1/100 dilution staining PARP in human breast carcinoma by Immunohistochemistry, Paraffin embedded tissue in the absence or presence of the immunising peptide.

References for Anti-CCNL1 antibody (ab53045)

ab53045 has not yet been referenced specifically in any publications.

Product Wall

Thank you for your enquiry. I have checked our database and it seems that we have an error on the datasheet. This product should be a CCNL1 antibody and not a Cyclin L1/L2 antibody. Also, the immunogen is actually a synthetic peptide derived fro...

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