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Products:Immunology >> Innate Immunity >> Chemokines >> Beta Chemokine Rec. (CCR)
Overview
Product name
Anti-CCR11 antibody
See all CCR11 products (4) ...
Description
Goat polyclonal to CCR11
Specificity
Peptide sequence is < 50 % identical to other human chemokine receptors in this region. Please note there are two proteins called CCR11. This antibody is useful in identifying CCR11 and CCRL1 (not CCR11 and CCRL2).
Tested applications
ELISA, ICC, IHC-P, WBmore details
Cross reactivity
Reacts with
Mouse, Human
Immunogen
Synthetic peptide: EQNQSTDYYYEENEMNGTYDYSQYELIC, corresponding to amino acids 4-31 of Human CCR11.
EQNQSTDYYY EENEMNGTYD YSQYELIC
Positive control
Human heart, lung or small intestine.
Properties
Form
Liquid
Storage instructions
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Storage buffer
PBS, 1mg/ml BSA, 0.1% sodium azide, pH7.2
Concentration
Concentration information loading...
Purity
Immunogen affinity purified
Clonality
Polyclonal
Isotype
IgG
Research areas
Immunology >> Innate Immunity >> Chemokines >> Beta Chemokine Rec. (CCR)
Applications
Show applications key
Our Abpromise guarantee covers the use of ab1660 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
ELISA
ELISA: 1/75000ELISA: 1/75000
ICC
ICC: 1/500ICC: 1/500
IHC-P: 1/250Perform heat mediated antigen retrieval before commencing with IHC staining protocol.(Recommend to perform with Dako buffer S-1700, pH 6, steam for 20 min, cool for 20 min)
WB: 1/1000Detects a band of approximately 45 kDa.(CCR11 has 351 amino acids with 3 glycosylation sites and 7 hydrophobic domains. 7TMs generally run slower than other proteins of similar MW)
Target
Function
Receptor for CCL2, CCL8, CCL13, CCL19, CCL21 and CCL25.
Tissue specificity
Predominantly expressed in heart. Lower expression in lung, pancreas, spleen, colon, skeletal muscle and small intestine.
Sequence similarities
Belongs to the G-protein coupled receptor 1 family.
Cellular localization
Cell membrane.
Target information above from: UniProt accessionQ9NPB9
The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010).
Alternative names
- C C chemokine receptor type 11 antibody
- C-C chemokine receptor type 11 antibody
- C-C CKR-11 antibody
see all
Database links
- Entrez Gene: 51554 Human
- Entrez Gene: 252837 Mouse
- Omim: 606065 Human
- SwissProt: Q9NPB9 Human
- SwissProt: Q8BYE1 Mouse
- SwissProt: Q924I3 Mouse
- Unigene: 310512 Human
- Unigene: 729361 Human
see all
Anti-CCR11 antibody images:
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - CCR11 antibody (ab1660)
Immunohistochemistry using ab1660 on human lung tissue section
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CCR11 antibody (ab1660)
Immunohistochemistry using ab1660 on human lung tissue section
Protocols
References for Anti-CCR11 antibody (ab1660)
This product has been referenced in:
- Zeng XHet al. Coexpression of atypical chemokine binders (ACBs) in breast cancer predicts better outcomes. Breast Cancer Res Treat 125:715-27 (2011). IHC-P; Human.Read more (PubMed: 20369284) »
- Feng LYet al. Involvement of a novel chemokine decoy receptor CCX-CKR in breast cancer growth, metastasis and patient survival. Clin Cancer Res 15:2962-70 (2009). WB, IHC; Human.Read more (PubMed: 19383822) »
See all 6 publications for this product
Publishing research using ab1660? Please let us know so that we can cite the reference in this datasheet
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"