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Function
High affinity receptor for the C-C type chemokines CCL17/TARC and CCL22/MDC. The activity of this receptor is mediated by G(i) proteins which activate a phosphatidylinositol-calcium second messenger system. Can function as a chemoattractant homing receptor on circulating memory lymphocytes and as a coreceptor for some primary HIV-2 isolates. In the CNS, could mediate hippocampal-neuron survival.
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Tissue specificity
Predominantly expressed in the thymus, in peripheral blood leukocytes, including T-cells, mostly CD4+ cells, and basophils, and in platelets; at lower levels, in the spleen and in monocytes. Detected also in macrophages, IL-2-activated natural killer cells and skin-homing memory T-cells, mostly the ones expressing the cutaneous lymphocyte antigen (CLA). Expressed in brain microvascular and coronary artery endothelial cells.
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Sequence similarities
Belongs to the G-protein coupled receptor 1 family.
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Post-translational
modifications
In natural killer cells, CCL22 binding induces phosphorylation on yet undefined Ser/Thr residues, most probably by beta-adrenergic receptor kinases 1 and 2.
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Cellular localization
Cell membrane.
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Information by UniProt
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Database links
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Alternative names
- C C chemokine receptor type 4 antibody
- C C CKR 4 antibody
- C-C chemokine receptor type 4 antibody
- C-C CKR-4 antibody
- CC CKR 4 antibody
- CC-CKR-4 antibody
- CCR 4 antibody
- CCR-4 antibody
- CCR4 antibody
- CCR4_HUMAN antibody
- CD194 antibody
- Chemokine (CC motif) receptor 4 antibody
- chemokine C C motif receptor 4 antibody
- ChemR13 antibody
- CKR4 antibody
- CMKBR 4 antibody
- CMKBR4 antibody
- HGCN 14099 antibody
- K5 5 antibody
- K5-5 antibody
- MGC88293 antibody
see all