Anti-CCRL2 antibody [MM0158-5A15] (ab89547)

Abreviews (5)Q&A (2)

Overview

  • Product name
    Anti-CCRL2 antibody [MM0158-5A15]
    See all CCRL2 primary antibodies
  • Description
    Mouse monoclonal [MM0158-5A15] to CCRL2
  • Host species
    Mouse
  • Specificity
    ab89547 recognises isoform 1 and 2
  • Tested applications
    Suitable for: Flow Cytmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Recombinant full length Human CCRL2 protein

Properties

Applications

Our Abpromise guarantee covers the use of ab89547 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
Flow Cyt 1/20 - 1/100.

Target

  • Function
    Receptor for CCL19 and chemerin/RARRES2. Does not appear to be a signaling receptor, but may have a role in modulating chemokine-triggered immune responses by capturing and internalizing CCL19 or by presenting RARRES2 ligand to CMKLR1, a functional signaling receptors. Plays a critical role for the development of Th2 responses.
  • Tissue specificity
    Expressed abundantly in immunal tissues such as spleen, fetal liver, lymph node and bone marrow. Strong expression also in lung and heart. Expressed in almost all hematopoietic cells including monocytes, macrophages, PMNs, T-cells (both CD4+ and CD8+), monocyte-derived iDCs, NK cells, and CD34+ progenitor cells. B cells expressed isoform 1 but not isoform 2. Up-regulated on synovial neutrophils of rheumatoid arthritis patients.
  • Sequence similarities
    Belongs to the G-protein coupled receptor 1 family.
  • Domain
    Lacks the conserved DRYLAIV motif in the second intracellular loop that is required for signaling of functional chemokine receptors.
  • Cellular localization
    Cell membrane.
  • Information by UniProt
  • Database links
    • Alternative names
      • C-C chemokine receptor-like 2 antibody
      • CCRL2 antibody
      • CCRL2_HUMAN antibody
      • Chemokine (C-C motif) receptor like 2 antibody
      • Chemokine receptor CCR11 antibody
      • Chemokine receptor X antibody
      • CKRX antibody
      • CRAM A antibody
      • CRAM B antibody
      • CRAMA antibody
      • CRAMB antibody
      • FLJ55815 antibody
      • HCR antibody
      • MGC116710 antibody
      • MGC34104 antibody
      • Putative MCP 1 chemokine receptor antibody
      • Putative MCP-1 chemokine receptor antibody
      see all

    References

    ab89547 has not yet been referenced specifically in any publications.

    Publishing research using ab89547? Please let us know so that we can cite the reference in this datasheet.

    Customer reviews and Q&As

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    2 Q&A

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    Votes: Highest First

    ReviewID: xxx AbID: 89547, Anti-CCRL2 antibody [MM0158-5A15] Rating: Below Average Image: Anti-CCRL2 antibody [MM0158-5A15] for Flow Cytometry (Human) Sample: Species: Human Type: Cell Specification: PBMC Preparation: Cell harvesting/tissue preparation...

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    Thank you for submitting an Abreview of ab89547. As you may have noticed, your review has now been published on our website.
    Since you obtained poor results using the antibody in a tested species and application, we would like to follow up on this...

    Read More

    ReviewID: xxx AbID: 89547, Anti-CCRL2 antibody [MM0158-5A15] Rating: Poor Image: Anti-CCRL2 antibody [MM0158-5A15] for Flow Cytometry (Mouse) Sample: Species: Mouse Type: Cell Specification: Whole blood Preparation: Cell harvesting/tissue preparation m...

    Read More

    Thank you for submitting an Abreview of ab89547. As you may have noticed, your review has now been published on our website.
    Since you obtained poor results using the antibody in a untested species (mouse), we would like to follow up on this with ...

    Read More

    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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