Anti-CD10 + CD19 antibody [FR4D11/F3 + CB19] (Dual color: FITC + PE) (ab1237)

Overview

  • Product nameAnti-CD10 + CD19 antibody [FR4D11/F3 + CB19] (Dual color: FITC + PE)
  • Description
    Mouse monoclonal [FR4D11/F3 + CB19] to CD10 + CD19 (Dual color: FITC + PE)
  • ConjugationDual color: FITC + PE
  • Tested applicationsFlow Cytmore details
  • Species reactivity
    Reacts with: Human
  • General notesThis product is a mixture of two clones: CD10 = Clone:FR4D11/F3, Isotype:IgG1, Label:FITC CD19 = Clone:CB19, Isotype:IgG1, Label:PE

Properties

Applications

Our Abpromise guarantee covers the use of ab1237 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
Flow Cyt
  • Application notesCharacterization of leukaemias and lymphomas in human lysed whole peripheral blood or mononuclear cells separated by density gradient.
    Childhood ALL prognosis (patients CD10+ have a better prognosis than CD10-)

    CD10(FITC) / CD19 (PE) immunofluorescence analysis can be performed on a flow cytometerequipped with an excitation source of 488nm and fitted with logarithmic amplifiers.

    10µl ofCD10(FITC) / CD19 (PE) is sufficient for labelling 1x106 cells.
  • Target

    • RelevanceThe CD10 antigen (Mw = 100kDa) or "Common Acute Lymphoblastic Leukaemia Antigen" (CALLA) is expressed on the majority of B lymphoid leukaemias. It is also present on a wide variety of normal and neoplastic cell types including renal epithelium, fibroblasts, granulocytes, pre B and pre T cells, and some neural cells and neoplastic cell types including lymphomas and melanomas. It is a cell surface enzyme with endopeptidase activity. CD19 antigen (MW = 95kDa) is present on 10-15% of human peripheral blood lymphocytes and approximately 60% of splenic lymphocytes. It is not expressed on T lymphocytes, granulocytes, activated T cells or monocytes. Moreover, CD19 is present on principal acute and chronic B cell leukemias and lymphomas.
    • Cellular localizationCD10: Membrane; single pass type II membrane protein. CD19: Membrane; single pass type I membrane protein.
    • Database links
    • Alternative names
      • Atriopeptidase antibody
      • B lymphocyte antigen CD19 antibody
      • CD10 antibody
      • CD19 antigen antibody
      • CD19 molecule antibody
      • Enkephalinase antibody
      • MME antibody
      • NEP antibody
      • Neprilysin antibody
      • Neutral endopeptidase antibody
      see all

    References for Anti-CD10 + CD19 antibody [FR4D11/F3 + CB19] (Dual color: FITC + PE) (ab1237)

    ab1237 has not yet been referenced specifically in any publications.

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