• Product name
    Anti-CD105 antibody [105C02]
    See all CD105 primary antibodies
  • Description
    Mouse monoclonal [105C02] to CD105
  • Tested applications
    Suitable for: IHC-Fr, IHC-P, WB, Flow Cytmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Purified GP160 from cell membrane glycoproteins of fresh non-T/non-B acute lymphoblastic leukemia cells.

  • Positive control
    • HUVEC cells.



Our Abpromise guarantee covers the use of ab44967 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-Fr Use at an assay dependent concentration. PubMed: 24714106
IHC-P 1/1000. Perform enzymatic antigen retrieval before commencing with IHC staining protocol.
WB 1/1000. Detects a band of approximately 95 kDa.
Flow Cyt Use at an assay dependent concentration. ab170190-Mouse monoclonal IgG1, is suitable for use as an isotype control with this antibody.


  • Function
    Major glycoprotein of vascular endothelium. May play a critical role in the binding of endothelial cells to integrins and/or other RGD receptors.
  • Tissue specificity
    Endoglin is restricted to endothelial cells in all tissues except bone marrow.
  • Involvement in disease
    Defects in ENG are the cause of hereditary hemorrhagic telangiectasia type 1 (HHT1) [MIM:187300, 108010]; also known as Osler-Rendu-Weber syndrome 1 (ORW1). HHT1 is an autosomal dominant multisystemic vascular dysplasia, characterized by recurrent epistaxis, muco-cutaneous telangiectases, gastro-intestinal hemorrhage, and pulmonary (PAVM), cerebral (CAVM) and hepatic arteriovenous malformations; all secondary manifestations of the underlying vascular dysplasia. Although the first symptom of HHT1 in children is generally nose bleed, there is an important clinical heterogeneity.
  • Cellular localization
  • Information by UniProt
  • Database links
  • Alternative names
    • AI528660 antibody
    • AI662476 antibody
    • CD 105 antibody
    • CD105 antibody
    • CD105 antigen antibody
    • EGLN_HUMAN antibody
    • END antibody
    • Endoglin antibody
    • Eng antibody
    • FLJ41744 antibody
    • HHT1 antibody
    • ORW antibody
    • ORW1 antibody
    • Osler Rendu Weber syndrome 1 antibody
    • RP11 228B15.2 antibody
    • S-endoglin antibody
    • SN6 antibody
    see all


This product has been referenced in:
  • Wang X  et al. Biocompatibility of biological material polylactic acid with stem cells from human exfoliated deciduous teeth. Biomed Rep 6:519-524 (2017). Read more (PubMed: 28515910) »
  • Hosseini SM  et al. Differentiation of human breast-milk stem cells to neural stem cells and neurons. Neurol Res Int 2014:807896 (2014). Read more (PubMed: 25506428) »

See all 4 Publications for this product

Customer reviews and Q&As

I am sorry this product did not perform as stated on the datasheet and for the inconvenience this has caused. As requested, I have issued a free of charge replacement for one vial of ab49679.

To check the status of the order please contact o...

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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Rabbit Tissue sections (Insitional back wound)
Antigen retrieval step
Insitional back wound
Blocking step
Dako Dual Endogenous Enzyme Block as blocking agent for 5 minute(s) · Concentration: 100% · Temperature: 37°C

Abcam user community

Verified customer

Submitted Jun 29 2016

Immunocytochemistry/ Immunofluorescence
Blocking step
BSA as blocking agent for 2 hour(s) and 0 minute(s) · Concentration: 1% · Temperature: 25°C
Human Cell (Human primary mesenchymal stem cells grown in 3-D)
Human primary mesenchymal stem cells grown in 3-D

Abcam user community

Verified customer

Submitted Feb 16 2015

Thank you for contacting Abcam.
Earlier today we discussed the Human Mesenchymal Stromal Cell Marker panel ab93758. Based on the information on the datasheet, I compiled the following information for you:
1. Positive selection (CD105, CD29, CD4...

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Hello! I have pasted the protocols below. Please let me know if you have any further questions!
Proteinase K Solution (Method 1) (20 ug/ml in TE Buffer, pH 8.0):

TE Buffer (50mM Tris Base, 1mM EDTA, 0.5% Triton X-100, pH 8.0):
Tris Bas...

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Thank you for contacting us. I have placed information abou the trypsin solution and enzymatic antigen retrieval below.
I hope this information is helpful to you. Please do not hesitate to contact us if you need any more advice or information. Read More

Thank you for contacting us.

I am sorry to hear you are experiencing difficulties with one of our products. We take product complaints very seriously, and investigate every product that we feel may not be performing correctly.

I am at...

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Thank you very much for your calls today and for letting us know about the trouble with ab44967 and these other CD105 antibodies.

As we discussed, I'm sending a free of charge vial of ab11414 on the order ***, which should arrive tomorrow. Pl...

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Thank you for your enquiry and interest in our products.

I can confirm that this panel contains 5 primary antibodies which recognize human mesenchymal stromal cells: ab6124, ab10559, ab23894, ab44967, ab52971. The datasheets can be found at t...

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Just wanted you to know I have found your order on our system. I will follow up with you shortly when have set up the replacement order.

1-10 of 15 Abreviews or Q&A


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