• Product nameAnti-CD105 antibody
    See all CD105 primary antibodies
  • Description
    Rabbit polyclonal to CD105
  • Tested applicationsSuitable for: IHC-Pmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Recombinant fragment, corresponding to amino acids 26-176 of Human CD105

  • Positive control
    • Human tonsil tissue.



Our Abpromise guarantee covers the use of ab74462 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
  • Application notesIHC-P: 1/50 for 30 minutes at room temperature.
    Staining of formalin fixed tissues requires boiling tissue sections in 10mM citrate buffer, pH 6.0 for 10 minutes followed by cooling at room temperature for 20 minutes.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • Target

    • FunctionMajor glycoprotein of vascular endothelium. May play a critical role in the binding of endothelial cells to integrins and/or other RGD receptors.
    • Tissue specificityEndoglin is restricted to endothelial cells in all tissues except bone marrow.
    • Involvement in diseaseDefects in ENG are the cause of hereditary hemorrhagic telangiectasia type 1 (HHT1) [MIM:187300, 108010]; also known as Osler-Rendu-Weber syndrome 1 (ORW1). HHT1 is an autosomal dominant multisystemic vascular dysplasia, characterized by recurrent epistaxis, muco-cutaneous telangiectases, gastro-intestinal hemorrhage, and pulmonary (PAVM), cerebral (CAVM) and hepatic arteriovenous malformations; all secondary manifestations of the underlying vascular dysplasia. Although the first symptom of HHT1 in children is generally nose bleed, there is an important clinical heterogeneity.
    • Cellular localizationMembrane.
    • Information by UniProt
    • Database links
    • Alternative names
      • AI528660 antibody
      • AI662476 antibody
      • CD 105 antibody
      • CD105 antibody
      • CD105 antigen antibody
      • EGLN_HUMAN antibody
      • END antibody
      • Endoglin antibody
      • Eng antibody
      • FLJ41744 antibody
      • HHT1 antibody
      • ORW antibody
      • ORW1 antibody
      • Osler Rendu Weber syndrome 1 antibody
      • RP11 228B15.2 antibody
      • S-endoglin antibody
      • SN6 antibody
      see all

    Anti-CD105 antibody images

    • ab74462, at 1/50 dilution, staining CD105 in formalin fixed, paraffin embedded human tonsil tissue by Immunohistochemistry.

    References for Anti-CD105 antibody (ab74462)

    ab74462 has not yet been referenced specifically in any publications.

    Product Wall

    I am sorry this product did not perform as stated on the datasheet and for the inconvenience this has caused. As requested, I have issued a free of charge replacement for one vial of ab49679.

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    As we discussed, I'm sending a free of charge vial of ab11414 on the order ***, which should arrive tomorrow. Pl...

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