Anti-CD105 antibody [MJ718] (FITC) (ab184667)

Overview

  • Product name
    Anti-CD105 antibody [MJ718] (FITC)
    See all CD105 primary antibodies
  • Description
    Rat monoclonal [MJ718] to CD105 (FITC)
  • Conjugation
    FITC. Ex: 493nm, Em: 528nm
  • Tested applications
    Suitable for: Flow Cytmore details
  • Species reactivity
    Reacts with: Mouse
  • Immunogen

    Tissue, cells or virus corresponding to Mouse CD105. ab184667 was produced by immunizing rats with inflamed mouse skin (murine stromal cell line). NCBI Accession No. NP_031958.2
    Database link: Q63961

  • Positive control
    • Mouse endothelial cells.

Properties

Applications

Our Abpromise guarantee covers the use of ab184667 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
Flow Cyt Use a concentration of 5 µg/ml.

in a volume of 100 µl





ab18446-Rat monoclonal IgG2a, is suitable for use as an isotype control with this antibody.

Target

  • Function
    Major glycoprotein of vascular endothelium. May play a critical role in the binding of endothelial cells to integrins and/or other RGD receptors.
  • Tissue specificity
    Endoglin is restricted to endothelial cells in all tissues except bone marrow.
  • Involvement in disease
    Defects in ENG are the cause of hereditary hemorrhagic telangiectasia type 1 (HHT1) [MIM:187300, 108010]; also known as Osler-Rendu-Weber syndrome 1 (ORW1). HHT1 is an autosomal dominant multisystemic vascular dysplasia, characterized by recurrent epistaxis, muco-cutaneous telangiectases, gastro-intestinal hemorrhage, and pulmonary (PAVM), cerebral (CAVM) and hepatic arteriovenous malformations; all secondary manifestations of the underlying vascular dysplasia. Although the first symptom of HHT1 in children is generally nose bleed, there is an important clinical heterogeneity.
  • Cellular localization
    Membrane.
  • Information by UniProt
  • Database links
  • Alternative names
    • AI528660 antibody
    • AI662476 antibody
    • CD 105 antibody
    • CD105 antibody
    • CD105 antigen antibody
    • EGLN_HUMAN antibody
    • END antibody
    • Endoglin antibody
    • Eng antibody
    • FLJ41744 antibody
    • HHT1 antibody
    • ORW antibody
    • ORW1 antibody
    • Osler Rendu Weber syndrome 1 antibody
    • RP11 228B15.2 antibody
    • S-endoglin antibody
    • SN6 antibody
    see all

Images

  • Flow cytometry analysis of mouse endothelial cells labeling CD105. Upper panel: no primary antibody; Middle panel: solely conjugated secondary antibody; Lower panel: ab184667 at 5 µg/ml.

  • Flow cytometry analysis of mouse endothelial cells labeling CD105, using ab184667 at 5 µg/ml (red-filled histogram).

References

ab184667 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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