• Product nameAnti-CD11a antibody [I21/7]
    See all CD11a primary antibodies
  • Description
    Rat monoclonal [I21/7] to CD11a
  • SpecificityThe monoclonal antibody I21/7 reacts with the alpha subunit of mouse CD11a, also known as Leukocyte Function-associated Antigen 1 (LFA1). CD11a is expressed on thymocytes, T and B lymphocytes, and on non lymphoid cells in the bone marrow.
  • Tested applicationsSuitable for: Flow Cyt, IP, IHC-Frmore details
  • Species reactivity
    Reacts with: Mouse
  • Immunogen

    The details of the immunogen for this antibody are not available.



Our Abpromise guarantee covers the use of ab25383 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
Flow Cyt Use at an assay dependent concentration. ab18450-Rat monoclonal IgG2a, is suitable for use as an isotype control with this antibody.
IP Use at an assay dependent concentration.
IHC-Fr Use at an assay dependent concentration.


  • FunctionIntegrin alpha-L/beta-2 is a receptor for ICAM1, ICAM2, ICAM3 and ICAM4. It is involved in a variety of immune phenomena including leukocyte-endothelial cell interaction, cytotoxic T-cell mediated killing, and antibody dependent killing by granulocytes and monocytes.
  • Tissue specificityLeukocytes.
  • Sequence similaritiesBelongs to the integrin alpha chain family.
    Contains 7 FG-GAP repeats.
    Contains 1 VWFA domain.
  • DomainThe integrin I-domain (insert) is a VWFA domain. Integrins with I-domains do not undergo protease cleavage.
  • Cellular localizationMembrane.
  • Information by UniProt
  • Database links
  • Alternative names
    • Lymphocyte function associated antigen, type 1, alpha subunit antibody
    • Antigen CD11A (p180), lymphocyte function associated antigen 1, alpha polypeptide antibody
    • Antigen CD11A antibody
    • CD 11a antibody
    • CD11 antigen-like family member A antibody
    • CD11a antibody
    • CD11a antigen antibody
    • Integrin Alpha L antibody
    • Integrin alpha-L antibody
    • Integrin gene promoter antibody
    • Integrin, alpha L (antigen CD11A (p180), lymphocyte function associated antigen 1; alpha polypeptide) antibody
    • ITAL_HUMAN antibody
    • Itgal antibody
    • ITGAL protein antibody
    • Leukocyte adhesion glycoprotein LFA 1 alpha chain antibody
    • Leukocyte adhesion glycoprotein LFA-1 alpha chain antibody
    • Leukocyte Adhesion Glycoprotein LFA1 Alpha Chain antibody
    • Leukocyte function associated molecule 1 alpha chain antibody
    • Leukocyte function-associated molecule 1 alpha chain antibody
    • LFA 1 alpha (LFA1A) antibody
    • LFA 1 alpha antibody
    • LFA 1 antibody
    • LFA 1A antibody
    • LFA-1A antibody
    • LFA1A antibody
    • Ly15 antibody
    • Ly21 antibody
    • Lymphocyte function associated antigen 1 antibody
    • Lymphocyte Function Associated Antigen Type 1 alpha antibody
    • lymphocyte function-associated antigen 1, alpha polypeptide antibody
    • p180 antibody
    see all

References for Anti-CD11a antibody [I21/7] (ab25383)

This product has been referenced in:
  • Connolly MK  et al. Treatment of murine lupus with monoclonal antibodies to lymphocyte function-associated antigen-1: dose-dependent inhibition of autoantibody production and blockade of the immune response to therapy. Clin Immunol Immunopathol 72:198-203 (1994). Read more (PubMed: 8050193) »

See 1 Publication for this product

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Thank you for getting back to us. I am sorry that the suggestions have not improved the results, it may be that the antibody is not suitable for Western blotting, we have now updated our datasheet to reflect this. I am very sorry for this as I know you...

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Thank you for taking time to complete our questionnaire. I am sorry to hear that this antibody is not providing satisfactory results. The details provided will enable us to investigate this case and will provide us with vital information for monitoring...

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Thank you for your recent telephone enquiry. I am sorry it has taken some time to receive further details from the originator of this product. They are not able to provide the specific testing protocol for this antibody. They do suggest a starting ...

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Thank you for your enquiry. Because we list Western blot as a tested application, we would guarantee the antibody to work with the tested species. We do not have a Western blot image at this time, but that does not diminish our guarantee. If you should...

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