The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Use at an assay dependent concentration.
FunctionIntegrin alpha-M/beta-2 is implicated in various adhesive interactions of monocytes, macrophages and granulocytes as well as in mediating the uptake of complement-coated particles. It is identical with CR-3, the receptor for the iC3b fragment of the third complement component. It probably recognizes the R-G-D peptide in C3b. Integrin alpha-M/beta-2 is also a receptor for fibrinogen, factor X and ICAM1. It recognizes P1 and P2 peptides of fibrinogen gamma chain.
Tissue specificityPredominantly expressed in monocytes and granulocytes.
Involvement in diseaseGenetic variations in ITGAM has been associated with susceptibility to systemic lupus erythematosus type 6 (SLEB6) [MIM:609939]. Systemic lupus erythematosus (SLE) is a chronic, inflammatory and often febrile multisystemic disorder of connective tissue. It affects principally the skin, joints, kidneys and serosal membranes. It is thought to represent a failure of the regulatory mechanisms of the autoimmune system.
Sequence similaritiesBelongs to the integrin alpha chain family. Contains 7 FG-GAP repeats. Contains 1 VWFA domain.
DomainThe integrin I-domain (insert) is a VWFA domain. Integrins with I-domains do not undergo protease cleavage.
Complement receptor type 3, alpha subunit antibody
CR 3 alpha chain (CR3A) antibody
CR 3 alpha chain antibody
CR-3 alpha chain antibody
Integrin Alpha M antibody
Integrin alpha M chain antibody
Integrin alpha-M antibody
Integrin beta 2 alpha subunit antibody
Integrin subunit alpha M antibody
integrin, alpha M (complement component 3 receptor 3 subunit) antibody
Leukocyte adhesion receptor MO1 antibody
MAC 1 antibody
Mac1, alpha subunit antibody
Macrophage antigen alpha polypeptide antibody
Mo1, alpha subunit antibody
Neutrophil adherence receptor alpha M subunit antibody
Neutrophil adherence receptor antibody
References for Anti-CD11b antibody [M1/70] (Allophycocyanin) (ab25482)
This product has been referenced in:
Sanchez-Madrid F et al. Mapping of antigenic and functional epitopes on the alpha- and beta-subunits of two related mouse glycoproteins involved in cell interactions, LFA-1 and Mac-1. J Exp Med158:586-602 (1983).
Read more (PubMed: 6193226) »
Flotte TJ et al. Dendritic cell and macrophage staining by monoclonal antibodies in tissue sections and epidermal sheets. Am J Pathol111:112-24 (1983).
Read more (PubMed: 6340516) »