Anti-CD11+CD18 antibody [YKIX 490.6.4] (ab23397)

Overview

  • Product nameAnti-CD11+CD18 antibody [YKIX 490.6.4]
    See all CD11+CD18 primary antibodies
  • Description
    Rat monoclonal [YKIX 490.6.4] to CD11+CD18
  • Tested applicationsSuitable for: Flow Cyt, IPmore details
    Unsuitable for: IHC-Fr,IHC-P or IHC-R
  • Species reactivity
    Reacts with: Dog
  • Immunogen

    Tissue/ cell preparation (Dog). Canine thymocytes.

  • General notes


    This antibody has been assigned to the canine CD11/18 group, recognising a cell surface antigen of 90/180kD which is expressed by most leucocytes, although expression on peripheral blood lymphocytes is weak. This antibody blocks T cell proliferation, CTL and ADCC killing, and homotypic adhesion.

Properties

Applications

Our Abpromise guarantee covers the use of ab23397 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
Flow Cyt 1/50 - 1/100.

Use 10µl of working dilution for 106 cells in 100 µl.





ab18703-Rat monoclonal IgG2c, is suitable for use as an isotype control with this antibody.
IP Use at an assay dependent concentration.
  • Application notesIs unsuitable for IHC-Fr,IHC-P or IHC-R.
  • Target

    • FunctionIntegrin alpha-L/beta-2 is a receptor for ICAM1, ICAM2, ICAM3 and ICAM4. It is involved in a variety of immune phenomena including leukocyte-endothelial cell interaction, cytotoxic T-cell mediated killing, and antibody dependent killing by granulocytes and monocytes.
    • Tissue specificityLeukocytes.
    • Sequence similaritiesBelongs to the integrin alpha chain family.
      Contains 7 FG-GAP repeats.
      Contains 1 VWFA domain.
    • DomainThe integrin I-domain (insert) is a VWFA domain. Integrins with I-domains do not undergo protease cleavage.
    • Cellular localizationMembrane.
    • Information by UniProt
    • Alternative names
      • Antigen CD11A (p180), lymphocyte function associated antigen 1, alpha polypeptide antibody
      • CD11 antigen-like family member A antibody
      • CD11a antibody
      • CD18 antibody
      • CR3 antibody
      • Integrin alpha-L antibody
      • Integrin beta 2 antibody
      • Integrin gene promoter antibody
      • ITAL_HUMAN antibody
      • Itgal antibody
      • ITGAM antibody
      • ITGB2 antibody
      • LAD antibody
      • Leukocyte adhesion glycoprotein LFA-1 alpha chain antibody
      • Leukocyte function-associated molecule 1 alpha chain antibody
      • LFA 1 alpha antibody
      • LFA 1 antibody
      • LFA-1A antibody
      • LFA1 antibody
      • LFA1A antibody
      • Lymphocyte function associated antigen 1 antibody
      • MAC1 antibody
      • MFI7 antibody
      • MO1A antibody
      see all

    References for Anti-CD11+CD18 antibody [YKIX 490.6.4] (ab23397)

    ab23397 has not yet been referenced specifically in any publications.

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"