• Product nameAnti-CD130 (gp130) antibody [B-P8]
    See all CD130 (gp130) primary antibodies
  • Description
    Mouse monoclonal [B-P8] to CD130 (gp130)
  • SpecificityThis antibody is specific for CD130. (Recognises the soluble antigen.)
  • Tested applicationsSuitable for: Flow Cytmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Full length native CD130 (gp130) protein (purified, soluble) (Human)



Our Abpromise guarantee covers the use of ab27355 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
Flow Cyt
  • Application notesFlow Cyt: Use at an assay dependent dilution.
    Inhibits CNTF activity and binding to gp130.
    Induces gp130 activation, Jak 1, Jak 2, Stat 1 and Stat 3 phosphorylation.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • Target

    • FunctionSignal-transducing molecule. The receptor systems for IL6, LIF, OSM, CNTF, IL11, CTF1 and BSF3 can utilize gp130 for initiating signal transmission. Binds to IL6/IL6R (alpha chain) complex, resulting in the formation of high-affinity IL6 binding sites, and transduces the signal. Does not bind IL6. May have a role in embryonic development (By similarity). The type I OSM receptor is capable of transducing OSM-specific signaling events.
    • Tissue specificityFound in all the tissues and cell lines examined. Expression not restricted to IL6 responsive cells.
    • Sequence similaritiesBelongs to the type I cytokine receptor family. Type 2 subfamily.
      Contains 5 fibronectin type-III domains.
      Contains 1 Ig-like C2-type (immunoglobulin-like) domain.
    • DomainThe WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.
      The box 1 motif is required for JAK interaction and/or activation.
    • Post-translational
      Phosphorylation of Ser-782 down-regulates cell surface expression.
      Heavily N-glycosylated.
    • Cellular localizationSecreted and Cell membrane.
    • Information by UniProt
    • Database links
    • Alternative names
      • CD130 antibody
      • CD130 antigen antibody
      • CDw130 antibody
      • gp130 antibody
      • GP130 RAPS antibody
      • IL 6R beta antibody
      • IL-6 receptor subunit beta antibody
      • IL-6R subunit beta antibody
      • IL-6R-beta antibody
      • IL-6RB antibody
      • IL6 ST antibody
      • IL6RB_HUMAN antibody
      • IL6ST antibody
      • Interleukin 6 receptor subunit beta antibody
      • Interleukin receptor beta chain antibody
      • Interleukin-6 receptor subunit beta antibody
      • Interleukin-6 signal transducer antibody
      • Membrane glycoprotein 130 antibody
      • Membrane glycoprotein gp130 antibody
      • Oncostatin M receptor antibody
      • Oncostatin M receptor alpha subunit antibody
      • Oncostatin-M receptor subunit alpha antibody
      see all

    Anti-CD130 (gp130) antibody [B-P8] images

    • Ab27355, staining CD130 (gp130) of Eahy 926 cell line by Flow Cytometry.

    References for Anti-CD130 (gp130) antibody [B-P8] (ab27355)

    This product has been referenced in:
    • Chevalier S  et al. Interleukin-6 family of cytokines induced activation of different functional sites expressed by gp130 transducing protein. J Biol Chem 271:14764-72 (1996). Read more (PubMed: 8662918) »

    See 1 Publication for this product

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