Overview

  • Product nameAnti-CD130 (gp130) antibody [B-P8]
    See all CD130 (gp130) primary antibodies
  • Description
    Mouse monoclonal [B-P8] to CD130 (gp130)
  • SpecificityThis antibody is specific for CD130. (Recognises the soluble antigen.)
  • Tested applicationsSuitable for: Flow Cytmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Full length native CD130 (gp130) protein (purified, soluble) (Human)

Properties

Applications

Our Abpromise guarantee covers the use of ab27355 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
Flow Cyt
  • Application notesFlow Cyt: Use at an assay dependent dilution.
    Inhibits CNTF activity and binding to gp130.
    Induces gp130 activation, Jak 1, Jak 2, Stat 1 and Stat 3 phosphorylation.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • Target

    • FunctionSignal-transducing molecule. The receptor systems for IL6, LIF, OSM, CNTF, IL11, CTF1 and BSF3 can utilize gp130 for initiating signal transmission. Binds to IL6/IL6R (alpha chain) complex, resulting in the formation of high-affinity IL6 binding sites, and transduces the signal. Does not bind IL6. May have a role in embryonic development (By similarity). The type I OSM receptor is capable of transducing OSM-specific signaling events.
    • Tissue specificityFound in all the tissues and cell lines examined. Expression not restricted to IL6 responsive cells.
    • Sequence similaritiesBelongs to the type I cytokine receptor family. Type 2 subfamily.
      Contains 5 fibronectin type-III domains.
      Contains 1 Ig-like C2-type (immunoglobulin-like) domain.
    • DomainThe WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.
      The box 1 motif is required for JAK interaction and/or activation.
    • Post-translational
      modifications
      Phosphorylation of Ser-782 down-regulates cell surface expression.
      Heavily N-glycosylated.
    • Cellular localizationSecreted and Cell membrane.
    • Information by UniProt
    • Database links
    • Alternative names
      • CD130 antibody
      • CD130 antigen antibody
      • CDw130 antibody
      • gp130 antibody
      • GP130 RAPS antibody
      • IL 6R beta antibody
      • IL-6 receptor subunit beta antibody
      • IL-6R subunit beta antibody
      • IL-6R-beta antibody
      • IL-6RB antibody
      • IL6 ST antibody
      • IL6RB_HUMAN antibody
      • IL6ST antibody
      • Interleukin 6 receptor subunit beta antibody
      • Interleukin receptor beta chain antibody
      • Interleukin-6 receptor subunit beta antibody
      • Interleukin-6 signal transducer antibody
      • Membrane glycoprotein 130 antibody
      • Membrane glycoprotein gp130 antibody
      • Oncostatin M receptor antibody
      • Oncostatin M receptor alpha subunit antibody
      • Oncostatin-M receptor subunit alpha antibody
      see all

    Anti-CD130 (gp130) antibody [B-P8] images

    • Ab27355, staining CD130 (gp130) of Eahy 926 cell line by Flow Cytometry.

    References for Anti-CD130 (gp130) antibody [B-P8] (ab27355)

    This product has been referenced in:
    • Chevalier S  et al. Interleukin-6 family of cytokines induced activation of different functional sites expressed by gp130 transducing protein. J Biol Chem 271:14764-72 (1996). Read more (PubMed: 8662918) »

    See 1 Publication for this product

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"