Anti-CD130 (gp130) antibody [B-R3] (ab47217)


  • Product nameAnti-CD130 (gp130) antibody [B-R3]
    See all CD130 (gp130) primary antibodies
  • Description
    Mouse monoclonal [B-R3] to CD130 (gp130)
  • Tested applicationsSuitable for: Flow Cyt, Inhibition Assaymore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Natural soluble human CD130 (gp130).

  • General notes

    This antibody recognizes the soluble antigen of CD130 (gp130).



Our Abpromise guarantee covers the use of ab47217 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
Flow Cyt Use at an assay dependent concentration.

Use 0.5µg/test.

ab170191-Mouse monoclonal IgG2a, is suitable for use as an isotype control with this antibody.
Inhibition Assay Use at an assay dependent concentration.

Use 1/10 dilution from 50µg/ml to 10-1 µg/ml. Inhibits IL6, IL11, CNTF, LIF and OSM activities as well as OSM and CNTF binding to gp130.


  • FunctionSignal-transducing molecule. The receptor systems for IL6, LIF, OSM, CNTF, IL11, CTF1 and BSF3 can utilize gp130 for initiating signal transmission. Binds to IL6/IL6R (alpha chain) complex, resulting in the formation of high-affinity IL6 binding sites, and transduces the signal. Does not bind IL6. May have a role in embryonic development (By similarity). The type I OSM receptor is capable of transducing OSM-specific signaling events.
  • Tissue specificityFound in all the tissues and cell lines examined. Expression not restricted to IL6 responsive cells.
  • Sequence similaritiesBelongs to the type I cytokine receptor family. Type 2 subfamily.
    Contains 5 fibronectin type-III domains.
    Contains 1 Ig-like C2-type (immunoglobulin-like) domain.
  • DomainThe WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.
    The box 1 motif is required for JAK interaction and/or activation.
  • Post-translational
    Phosphorylation of Ser-782 down-regulates cell surface expression.
    Heavily N-glycosylated.
  • Cellular localizationSecreted and Cell membrane.
  • Information by UniProt
  • Database links
  • Alternative names
    • CD130 antibody
    • CD130 antigen antibody
    • CDw130 antibody
    • gp130 antibody
    • GP130 RAPS antibody
    • IL 6R beta antibody
    • IL-6 receptor subunit beta antibody
    • IL-6R subunit beta antibody
    • IL-6R-beta antibody
    • IL-6RB antibody
    • IL6 ST antibody
    • IL6RB_HUMAN antibody
    • IL6ST antibody
    • Interleukin 6 receptor subunit beta antibody
    • Interleukin receptor beta chain antibody
    • Interleukin-6 receptor subunit beta antibody
    • Interleukin-6 signal transducer antibody
    • Membrane glycoprotein 130 antibody
    • Membrane glycoprotein gp130 antibody
    • Oncostatin M receptor antibody
    • Oncostatin M receptor alpha subunit antibody
    • Oncostatin-M receptor subunit alpha antibody
    see all

Anti-CD130 (gp130) antibody [B-R3] images

  • Ab47217, staining CD130 (gp130) by Flow Cytometry.

References for Anti-CD130 (gp130) antibody [B-R3] (ab47217)

ab47217 has not yet been referenced specifically in any publications.

Product Wall

Vielen Dank fuer Ihre Rueckmeldung. Es freut mich zu hören, dass Sie unser Angebot unseren Antikörper ab27357 im Inhibitionsassay zu testen, annehmen möchten. DISCOUNT CODE: xxx Ablaufdatum: Wie am Telefon besprochen, können Sie den ...

Read More

Vielen Dank für Ihren Anruf und für Ihr Interesse an unseren Produkten. Wie am Telefon besprochen, kann ich Ihnen für den CD130- Antikörperklon [B-P4] ab27357 das Testangebot machen, falls Sie den Inhibitionsassay austesten möchten (Details siehe un...

Read More