A crude mixture of Human urinary proteins precipitated by ammonium sulphate from the urine of a patient suffering from proteinuria.
Human blood cells.
Purified antibody is conjugated with tandem dye PerCP/Cy5.5® under optimum conditions. The conjugate is purified by size-exclusion chromatography and adjusted for direct use. No reconstitution is necessary.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Use 4µl for 106 cells.
(or 100 µl of whole blood).
ab157226 - Mouse monoclonal IgG1, is suitable for use as an isotype control with this antibody.
Cooperates with MD-2 and TLR4 to mediate the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MyD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Up-regulates cell surface molecules, including adhesion molecules.
Expressed strongly on the surface of monocytes and weakly on the surface of granulocytes; also expressed by most tissue macrophages.
Contains 11 LRR (leucine-rich) repeats.
N- and O- glycosylated. O-glycosylated with a core 1 or possibly core 8 glycan.
Sing A et al. Yersinia V-antigen exploits toll-like receptor 2 and CD14 for interleukin 10-mediated immunosuppression. J Exp Med196:1017-24 (2002).
Read more (PubMed: 12391013) »
Funda DP et al. CD14 is expressed and released as soluble CD14 by human intestinal epithelial cells in vitro: lipopolysaccharide activation of epithelial cells revisited. Infect Immun69:3772-81 (2001).
Read more (PubMed: 11349042) »