Overview

Description

  • Nature
    Synthetic
  • Amino Acid Sequence
    • Species
      Human
    • Sequence
      C-KRVDADADPRQYAD
    • Amino acids
      71 to 84

Associated products

Specifications

Our Abpromise guarantee covers the use of ab45882 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    Blocking - Blocking peptide for Anti-CD14 antibody (ab45870)

  • Form
    Liquid
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

General Info

  • Alternative names
    • CD 14
    • CD_antigen=CD14
    • CD14
    • CD14 antigen
    • CD14 molecule
    • CD14_HUMAN
    • LPS-R
    • Mo2
    • Monocyte differentiation antigen CD14
    • Monocyte differentiation antigen CD14 urinary form
    • Monocyte differentiation antigen CD14, membrane-bound form
    • Myeloid cell specific leucine rich glycoprotein
    • Myeloid cell-specific leucine-rich glycoprotein
    see all
  • Function
    Cooperates with MD-2 and TLR4 to mediate the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MyD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Up-regulates cell surface molecules, including adhesion molecules.
  • Tissue specificity
    Expressed strongly on the surface of monocytes and weakly on the surface of granulocytes; also expressed by most tissue macrophages.
  • Sequence similarities
    Contains 11 LRR (leucine-rich) repeats.
  • Post-translational
    modifications
    N- and O- glycosylated. O-glycosylated with a core 1 or possibly core 8 glycan.
  • Cellular localization
    Cell membrane.
  • Information by UniProt

References

ab45882 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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