Specificityab91153 reacts with the promyelocytes, myelocytes and polymorphonuclear cells. It does not react with platelets and cells of the T and B lymphocyte lineage. ab91153 recognizes the carbohydrate structure 3-fucosyl-N-acetyl-lactosamine.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Use 20µl for 106 cells.
RelevanceCD15 is a carbohydrate adhesion molecule (and not a protein) that mediates phagocytosis and chemotaxis.
Synthesis is directed by FUT4 in lymphoid cells and mature granulocytes, and by FUT9 in promyelocytes and monocytes.
Cellular localizationGolgi Apparatus; Membrane-bound form in trans cisternae of Golgi.