Overview

  • Product nameAnti-CD1a antibody [NA1/34-HLK]
    See all CD1a primary antibodies
  • Description
    Mouse monoclonal [NA1/34-HLK] to CD1a
  • Specificityab24055 recognises the human CD1a cell surface glycoprotein, a 49kD molecule expressed in association with beta 2 microglobulin. CD1a is expressed strongly by cortical thymocytes, and also by Langerhans cells and interdigitating cells. NA1/34 does not precipitate out B2m, and SDS PAGE experiments performed by McMichael, A.J.et al.(1979) suggest that NA1/34 recognises a single protein component. From this information it seems very likely that the epitope is not found on the B2m part of the protein.
  • Tested applicationsSuitable for: Flow Cytmore details
  • Species reactivity
    Reacts with: Dog, Human, Monkey
  • Immunogen

    Thymocytes (Human).

Properties

  • FormLiquid
  • Storage instructionsShipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term.
  • Storage bufferPreservative: 0.09% Sodium Azide
    Constituents: 1% BSA, PBS, pH 7.4
  • Concentration information loading...
  • PurityIgG fraction
  • Purification notesPurified IgG prepared by ion exchange chromatography
  • ClonalityMonoclonal
  • Clone numberNA1/34-HLK
  • MyelomaNS1/1-Ag4-1
  • IsotypeIgG2a
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab24055 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
Flow Cyt 1/50 - 1/100. Use 10 µl of this concentration to label 106 cells in 100µl.



ab170191-Mouse monoclonal IgG2a, is suitable for use as an isotype control with this antibody.

Target

  • FunctionAntigen-presenting protein that binds self and non-self lipid and glycolipid antigens and presents them to T-cell receptors on natural killer T-cells.
  • Tissue specificityExpressed on cortical thymocytes, epidermal Langerhans cells, dendritic cells, on certain T-cell leukemias, and in various other tissues.
  • Sequence similaritiesContains 1 Ig-like (immunoglobulin-like) domain.
  • Cellular localizationCell membrane. Endosome membrane. Subject to intracellular trafficking between the cell membrane and endosomes. Localizes to cell surface lipid rafts.
  • Information by UniProt
  • Database links
  • Alternative names
    • CD 1a antibody
    • CD1 antibody
    • CD1a antibody
    • CD1A Antigen antibody
    • CD1A antigen, a polypeptide antibody
    • CD1a molecule antibody
    • CD1A_HUMAN antibody
    • cluster of differentiation 1 A antibody
    • cortical thymocyte antigen CD1A antibody
    • differentiation antigen CD1 alpha 3 antibody
    • epidermal dendritic cell marker CD1a antibody
    • FCB 6 antibody
    • FCB6 antibody
    • HTA 1 antibody
    • HTA1 antibody
    • hTa1 thymocyte antigen antibody
    • OTTHUMP00000018907 antibody
    • R 4 antibody
    • R4 antibody
    • T 6 antibody
    • T-cell surface antigen T6/Leu-6 antibody
    • T-cell surface glycoprotein CD1a antibody
    • T6 antibody
    see all

References for Anti-CD1a antibody [NA1/34-HLK] (ab24055)

This product has been referenced in:
  • Qeska V  et al. Canine distemper virus infection leads to an inhibitory phenotype of monocyte-derived dendritic cells in vitro with reduced expression of co-stimulatory molecules and increased interleukin-10 transcription. PLoS One 9:e96121 (2014). Flow Cyt . Read more (PubMed: 24769532) »
  • West JA  et al. Polyclonal T-cells express CD1a in Langerhans cell histiocytosis (LCH) lesions. PLoS One 9:e109586 (2014). ICC ; Human . Read more (PubMed: 25343480) »

See all 6 Publications for this product

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