Overview

  • Product name
    Anti-CD1b+c antibody [B-B5]
    See all CD1b+c primary antibodies
  • Description
    Mouse monoclonal [B-B5] to CD1b+c
  • Specificity
    This antibody recognises CD1b+c proteins.
  • Tested applications
    Suitable for: Flow Cytmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Thymus cells and Jurkat cell line.

Properties

Applications

Our Abpromise guarantee covers the use of ab27296 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
Flow Cyt
  • Application notes
    Flow Cyt: Use 10µl for 106 cells or 100µl of whole blood.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • Target

    • Relevance
      CD1B and CD1C are members of the CD1 family of major histocompatibility (MHC)-like glycoproteins. CD1 proteins mediate the presentation of lipid and glycolipid antigens to T cells. The CD1B protein localizes to late endosomes and lysosomes via a tyrosine-based motif in the cytoplasmic tail, and requires vesicular acidification to bind lipid antigens. The human genome contains five CD1 family genes, clustered on chromosome 1. CD1 family members are thought to differ in their cellular localization and specificity for lipid ligands.
    • Cellular localization
      Single-pass type I membrane protein.
    • Database links
    • Alternative names
      • CD1 antibody
      • CD1B antigen antibody
      • CD1b molecule antibody
      • CD1C antigen antibody
      • CD1c molecule antibody
      • R1 antibody
      • R7 antibody
      see all

    Images

    • A typical staining pattern with the B-B5 monoclonal antibody of Molt 4 cell lineAb27296, at a dilution of 10µl for 106 cells or 100 µl of whole blood, staining CD1b+c by Flow Cytometry.

    References

    This product has been referenced in:
    • Groot F  et al. Lactoferrin prevents dendritic cell-mediated human immunodeficiency virus type 1 transmission by blocking the DC-SIGN--gp120 interaction. J Virol 79:3009-15 (2005). Read more (PubMed: 15709021) »

    See 1 Publication for this product

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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