The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Use at an assay dependent concentration. ab18418-Mouse monoclonal IgG2b, is suitable for use as an isotype control with this antibody.
FunctionThis protein may be involved in the regulation of B-cell activation and proliferation.
Tissue specificityExpressed on B-cells.
Involvement in diseaseDefects in MS4A1 are the cause of immunodeficiency common variable type 5 (CVID5) [MIM:613495]; also called antibody deficiency due to CD20 defect. CVID5 is a primary immunodeficiency characterized by antibody deficiency, hypogammaglobulinemia, recurrent bacterial infections and an inability to mount an antibody response to antigen. The defect results from a failure of B-cell differentiation and impaired secretion of immunoglobulins; the numbers of circulating B cells is usually in the normal range, but can be low.
Sequence similaritiesBelongs to the MS4A family.
Post-translational modificationsPhosphorylated. Might be functionally regulated by protein kinase(s).
Fc Fragment of IgE high affinity I receptor for beta polypeptide antibody
High affinity immunoglobulin epsilon receptor subunit beta antibody
IgE Fc receptor subunit beta antibody
LEU 16 antibody
leukocyte surface antigen Leu 16 antibody
Leukocyte surface antigen Leu-16 antibody
Membrane spanning 4 domains A1 antibody
Membrane spanning 4 domains subfamily A member 2 antibody
Membrane-spanning 4-domains subfamily A member 1 antibody
References for Anti-CD20 antibody [2H7] (Biotin) (ab123487)
This product has been referenced in:
Polyak MJ & Deans JP Alanine-170 and proline-172 are critical determinants for extracellular CD20 epitopes; heterogeneity in the fine specificity of CD20 monoclonal antibodies is defined by additional requirements imposed by both amino acid sequence and quaternary structure. Blood99:3256-62 (2002).
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