The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Use a concentration of 0.003 - 0.01 µg/ml. Detects a band of approximately 35 kDa (predicted molecular weight: 33 kDa).Can be blocked with Human CD20 peptide (ab22803).
FunctionThis protein may be involved in the regulation of B-cell activation and proliferation.
Tissue specificityExpressed on B-cells.
Involvement in diseaseDefects in MS4A1 are the cause of immunodeficiency common variable type 5 (CVID5) [MIM:613495]; also called antibody deficiency due to CD20 defect. CVID5 is a primary immunodeficiency characterized by antibody deficiency, hypogammaglobulinemia, recurrent bacterial infections and an inability to mount an antibody response to antigen. The defect results from a failure of B-cell differentiation and impaired secretion of immunoglobulins; the numbers of circulating B cells is usually in the normal range, but can be low.
Sequence similaritiesBelongs to the MS4A family.
Post-translational modificationsPhosphorylated. Might be functionally regulated by protein kinase(s).