The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Use a concentration of 1 µg/ml. Detects a band of approximately 33 kDa.
Use a concentration of 3 µg/ml.
Use at an assay dependent concentration.
ab37355 - Mouse polyclonal IgG, is suitable for use as an isotype control with this antibody.
This protein may be involved in the regulation of B-cell activation and proliferation.
Expressed on B-cells.
Involvement in disease
Defects in MS4A1 are the cause of immunodeficiency common variable type 5 (CVID5) [MIM:613495]; also called antibody deficiency due to CD20 defect. CVID5 is a primary immunodeficiency characterized by antibody deficiency, hypogammaglobulinemia, recurrent bacterial infections and an inability to mount an antibody response to antigen. The defect results from a failure of B-cell differentiation and impaired secretion of immunoglobulins; the numbers of circulating B cells is usually in the normal range, but can be low.
Belongs to the MS4A family.
Phosphorylated. Might be functionally regulated by protein kinase(s).
Scialdone A et al. The HDAC inhibitor valproate induces a bivalent status of the CD20 promoter in CLL patients suggesting distinct epigenetic regulation of CD20 expression in CLL in vivo. Oncotarget8:37409-37422 (2017).
Read more (PubMed: 28445158) »
Liu L et al. Anemia and thrombocytopenia as initial symptoms of occult breast cancer with bone marrow metastasis: A case report. Medicine (Baltimore)96:e8529 (2017).
Read more (PubMed: 29137058) »