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Products:Immunology >> Adaptive Immunity >> B Cells >> CD
Overview
Product name
Anti-CD21 antibody [BB6-11C9.6] (FITC)
See all CD21 products (20) ...
Description
Mouse monoclonal [BB6-11C9.6] to CD21 (FITC)
Conjugation
FITC
Specificity
ab24887 recognises Porcine CD21.
Tested applications
Flow Cyt, IHC-Fr, IPmore details
Cross reactivity
Reacts with
Pig
Immunogen
The details of the immunogen for this antibody are not available.
Properties
Form
Liquid
Storage instructions
Store at +4°C in the dark.
Storage buffer
Preservative: 0.1% Sodium Azide
Constituents: PBS
Concentration
Concentration information loading...
Purity
IgG fraction
Primary antibody notes
ab24887 stains the following percentages of surface immunoglobulin (sIg) positive cells in porcine lymphoid tissues: 92-96% in peripheral blood; 74-98% in mesenteric lymph nodes; 97-100% in ileal Peyer’s patches (ILPP); 93-97% in spleen; and 0% in thymus. The antibody does not stain B cells in cord blood or spleen from pig fetuses (105 days gestation).
Clonality
Monoclonal
Clone number
BB6-11C9.6
Isotype
IgG1
Light chain type
kappa
Research areas
Immunology >> Adaptive Immunity >> B Cells >> CD
Applications
Show applications key
Our Abpromise guarantee covers the use of ab24887 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Flow Cyt: Use 1µg for 106 cells.
IHC-Fr: Use at an assay dependent dilution.
IP: Use at an assay dependent dilution.
Target
Function
Receptor for complement C3Dd, for the Epstein-Barr virus on human B-cells and T-cells and for HNRPU. Participates in B lymphocytes activation.
Tissue specificity
Mature B-lymphocytes, T-lymphocytes, pharyngeal epithelial cells, astrocytes and follicular dendritic cells of the spleen.
Involvement in disease
Genetic variations in CR2 are associated with susceptibility to systemic lupus erythematosus type 9 (SLEB9) [MIM:610927]. Systemic lupus erythematosus (SLE) is a chronic autoimmune disease with a complex genetic basis. SLE is an inflammatory, and often febrile multisystemic disorder of connective tissue characterized principally by involvement of the skin, joints, kidneys, and serosal membranes. It is thought to represent a failure of the regulatory mechanisms of the autoimmune system.
Sequence similarities
Belongs to the receptors of complement activation (RCA) family.
Contains 15 Sushi (CCP/SCR) domains.
Cellular localization
Membrane.
Target information above from: UniProt accessionP20023
The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010).
Alternative names
- C3DR antibody
- CD 21 antibody
- CD21 antibody
see all
References for Anti-CD21 antibody [BB6-11C9.6] (FITC) (ab24887)
This product has been referenced in:
- Denham Set al. Monoclonal antibodies putatively identifying porcine B cells. Vet Immunol Immunopathol 60:317-28 (1998).Read more (PubMed: 9589570) »
See 1 publication for this product
Publishing research using ab24887? Please let us know so that we can cite the reference in this datasheet
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"