Anti-CD24 antibody [SN3 A5-2H10] (Biotin) (ab95546)


  • Product nameAnti-CD24 antibody [SN3 A5-2H10] (Biotin)
    See all CD24 primary antibodies
  • Description
    Mouse monoclonal [SN3 A5-2H10] to CD24 (Biotin)
  • ConjugationBiotin
  • Tested applicationsSuitable for: Flow Cytmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    full length CD24; Glycoproteins purified from human NALM-1 cell line

  • Positive control
    • Human peripheral blood leukocytes


Our Abpromise guarantee covers the use of ab95546 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
Flow Cyt Use 0.25µg for 105 cells. Cell number should be determined empirically but can range from 105 to 108 cells/test

ab18434-Mouse monoclonal IgG1, is suitable for use as an isotype control with this antibody.


  • FunctionModulates B-cell activation responses. Signaling could be triggered by the binding of a lectin-like ligand to the CD24 carbohydrates, and transduced by the release of second messengers derived from the GPI-anchor. Promotes AG-dependent proliferation of B-cells, and prevents their terminal differentiation into antibody-forming cells.
  • Tissue specificityB-cells. Expressed in a number of B-cell lines including P32/SH and Namalwa. Expressed in erythroleukemia cell and small cell lung carcinoma cell lines. Also expressed on the surface of T-cells.
  • Involvement in diseaseGenetic variations in CD24 are associated with susceptibility to multiple sclerosis (MS) [MIM:126200]. A multifactorial, inflammatory, demyelinating disease of the central nervous system. Sclerotic lesions are characterized by perivascular infiltration of monocytes and lymphocytes and appear as indurated areas in pathologic specimens (sclerosis in plaques). The pathological mechanism is regarded as an autoimmune attack of the myelin sheat, mediated by both cellular and humoral immunity. Clinical manifestations include visual loss, extra-ocular movement disorders, paresthesias, loss of sensation, weakness, dysarthria, spasticity, ataxia and bladder dysfunction. Genetic and environmental factors influence susceptibility to the disease. Note=Polymorphisms in CD24 may act as a genetic modifier for susceptibility and progression of MS in some populations, perhaps by affecting the efficiency of CD24 expression on the cell surface.
  • Sequence similaritiesBelongs to the CD24 family.
  • Post-translational
    Extensively O-glycosylated.
  • Cellular localizationCell membrane.
  • Information by UniProt
  • Database links
  • Alternative names
    • CD 24 antibody
    • CD24 antibody
    • CD24 antigen (small cell lung carcinoma cluster 4 antigen) antibody
    • CD24 antigen antibody
    • CD24 molecule antibody
    • CD24_HUMAN antibody
    • CD24A antibody
    • FLJ22950 antibody
    • FLJ43543 antibody
    • GPI linked surface mucin antibody
    • Heat stable antigen antibody
    • HSA antibody
    • MGC75043 antibody
    • Nectadrin antibody
    • Signal transducer CD24 antibody
    • Small cell lung carcinoma cluster 4 antigen antibody
    see all

Anti-CD24 antibody [SN3 A5-2H10] (Biotin) images

  • Staining of normal human peripheral blood cells with 0.125 µg of Mouse IgG1 ? Isotype Control Biotin (open histogram) or 0.125 µg of ab95546 (filled histogram) followed by Streptavidin PE. Cells in the large scatter population were used for analysis.

References for Anti-CD24 antibody [SN3 A5-2H10] (Biotin) (ab95546)

ab95546 has not yet been referenced specifically in any publications.

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