Anti-CD252 antibody - C-terminal (ab156285)

Overview

  • Product name
    Anti-CD252 antibody - C-terminal
    See all CD252 primary antibodies
  • Description
    Rabbit polyclonal to CD252 - C-terminal
  • Host species
    Rabbit
  • Specificity
    At least two isoforms of TNFSF4 are known to exist; ab156285 will detect both isoforms.
  • Tested applications
    Suitable for: WBmore details
  • Species reactivity
    Reacts with: Mouse, Rat, Human
  • Immunogen

    Synthetic peptide, corresponding to 14 amino acids near the C terminus of Human CD252 (NP_003317).

  • Positive control
    • Rat spleen tissue lysate.

Properties

Applications

Our Abpromise guarantee covers the use of ab156285 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 0.5 - 1 µg/ml. Predicted molecular weight: 21 kDa.

Target

  • Function
    Cytokine that binds to TNFRSF4. Co-stimulates T-cell proliferation and cytokine production.
  • Involvement in disease
    Genetic variations in TNFSF4 influence susceptibility to systemic lupus erythematosus (SLE) [MIM:152700]. SLE is a chronic, inflammatory and often febrile multisystemic disorder of connective tissue. It affects principally the skin, joints, kidneys and serosal membranes. It is thought to represent a failure of the regulatory mechanisms of the autoimmune system. Note=The upstream region of TNFSF4 contains a single risk haplotype for SLE, which is correlated with increased expression of both cell-surface TNFSF4 and TNFSF4 transcripts. Increased levels of TNFSF4 are thought to augment T cell-APC interaction and the functional consequences of T cell activation, thereby destabilizing peripheral tolerance.
  • Sequence similarities
    Belongs to the tumor necrosis factor family.
  • Cellular localization
    Membrane.
  • Information by UniProt
  • Database links
  • Alternative names
    • CD 134L antibody
    • CD 252 antibody
    • CD134 antibody
    • CD134 ligand antibody
    • CD134L antibody
    • CD252 antibody
    • CD252 antigen antibody
    • glycoprotein 34 kd antibody
    • Glycoprotein Gp34 antibody
    • GP34 antibody
    • OX-40L antibody
    • OX40 antigen ligand antibody
    • OX40 ligand antibody
    • OX40L antibody
    • TAX transcriptionally-activated glycoprotein 1 antibody
    • TNFL4_HUMAN antibody
    • Tnfsf4 antibody
    • Tumor necrosis factor (ligand) superfamily member 4 antibody
    • Tumor necrosis factor ligand superfamily member 4 antibody
    • TXGP1 antibody
    see all

Images

  • Lane 1 : Anti-CD252 antibody - C-terminal (ab156285) at 0.5 µg/ml
    Lane 2 : Anti-CD252 antibody - C-terminal (ab156285) at 1 µg/ml

    All lanes : Rat spleen tissue lysate

    Lysates/proteins at 15 µg per lane.

    Predicted band size: 21 kDa

References

ab156285 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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