CD26 antibody - Carboxyterminal end (ab28341)

Product Name 

CD26 antibody - Carboxyterminal end

Product type 

Primary antibodies

Description 

Rabbit polyclonal to CD26 - Carboxyterminal end

Immunogen 

Synthetic peptide based on the C terminal end of the catalytic domain of human CD26.

(Peptide available as ab41396.)

Reacts with 
(species key)

Hu, Ms, Rat

Specificity 

ab28341 does not recognize other DPP family members.

We have a range of domain specific antibodies for this target. For a full list please see all CD26 antibodies

Tested applications 
(see key)

WB

Abreviews 

Customer reviews (see key)

Read about Abreviews

Application notes 
(see key)

Recommended dilutions
WB: 1/1000 (colorimetric) - 1/5000 (chemiluminescent). Detects a band of approximately 110-120 kDa (predicted molecular weight: 88 kDa). EDTA/EGTA treatment of tissues or lysates is required to see latent zymogen. Dilution optimised using Chromogenic detection. Not yet tested in other applications. Optimal dilutions/concentrations should be determined by the end user.

Cellular localization 

Type II membrane protein. Also exists in a soluble form.

Research areas 

Cancer >> Cancer Metabolism >> Response to hypoxia
Stem Cells >> Hematopoietic Progenitors >> Lymphoid >> T Lymphocytic Lineage
Stem Cells >> Hematopoietic Progenitors >> Lymphoid >> B Lymphocytic Lineage
Cell Biology >> Proteolysis / Ubiquitin >> Proteolytic enzymes >> Serine protease >> DPPs
Immunology >> Cell Type Markers >> CD >> Adhesion
Immunology >> Cell Type Markers >> CD >> Non-lineage
Immunology >> Adaptive Immunity >> T Cells >> CD
Immunology >> Adaptive Immunity >> B Cells >> CD

Relevance 

CD26 [also known as dipeptidyl peptidase IV (DPP IV), adenosine deaminase (ADA) binding protein] is an atypical serine protease belonging to the prolyl oligopeptidase family. It is expressed on lymphocyte cells and is upregulated during T cell activation. CD26 is also expressed on activated B cells and natural killer cells and abundantly on epithelia. CD26 is implicated in a variety of biological functions including T cell activation, cell adhesion with extracellular matrix such as fibronectin or collagens, and in HIV infection.

Database links 

Raised in 

Rabbit

Clonality 

Polyclonal

Isotype 

IgG

Purity 

Immunogen affinity purified

Storage buffer 

Preservative: 0.05% Sodium Azide
Constituents: 50% Glycerol

Material safety datasheets (MSDS) for this product:
Glycerol MSDS
Sodium Azide MSDS

Purification notes 

The antibody has been peptide-affinity purified.

Form 

Liquid

Concentration 

1.000 mg/ml

Storage instructions 

Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

See below for CD26 antibody - Carboxyterminal end images, references, products related to ab28341 and other tools.

CD26 antibody - Carboxyterminal end images:

References for CD26 antibody - Carboxyterminal end (ab28341)

  This product has been used in:

Stechly L et al. Galectin-4-regulated delivery of glycoproteins to the brush border membrane of enterocyte-like cells. Traffic 10:438-50 (2009). WB. PubMed: 19192249

If you publish research using ab28341 please let us know so that we can cite the reference on this datasheet.

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