Use at an assay dependent concentration. Soluble TNFRSF7 (also called CD27) attenuates CD27 Ligand-induced proliferation of Human T-cells.
In the presence of 2.5 µg/mL of soluble TNFRSF7, 10µg/mL recombinant CD27 ligand, 2.5-10 µg/ml of ab89258 could attenuate proliferation of human T-cells by 50% (3H-thymidine Incorporation).
1/50 - 1/100. ab170190-Mouse monoclonal IgG1, is suitable for use as an isotype control with this antibody.
FunctionReceptor for CD70/CD27L. May play a role in survival of activated T-cells. May play a role in apoptosis through association with SIVA1.
Tissue specificityFound in most T-lymphocytes.
Sequence similaritiesContains 3 TNFR-Cys repeats.
Post-translational modificationsPhosphorylated and O-glycosylated.