Anti-CD3 + CD8 antibody [CA17.2A12 + YCATE 55.9] (Dual color: FITC + PE) (ab34266)

Overview

  • Product nameAnti-CD3 + CD8 antibody [CA17.2A12 + YCATE 55.9] (Dual color: FITC + PE)
  • Description
    Mouse monoclonal [CA17.2A12 + YCATE 55.9] to CD3 + CD8 (Dual color: FITC + PE)
  • ConjugationDual color: FITC + PE
  • Tested applicationsSuitable for: Flow Cytmore details
  • Species reactivity
    Reacts with: Dog
  • General notesThis product is a mixture of two clones: CD3 = Clone:CA17.2A12, Isotype:IgG1, Label:FITC. Raised in Mouse. CD8 = Clone:YCATE 55.9, Isotype:IgG1, Label:PE. Raised in Rat.

Properties

  • FormLiquid
  • Storage instructionsShipped at 4°C. Store at +4°C.
  • Storage bufferPreservative: 0.09% Sodium Azide
    Constituents: 1% BSA, PBS, pH 7.4
  • Concentration information loading...
  • ClonalityMonoclonal
  • Clone numberCA17.2A12 + YCATE 55.9
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab34266 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
Flow Cyt
  • Application notesFACS: Use Use 10µl for 106 cells in 100µl.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • Target

    • RelevanceThe CD8 antigen is a cell surface glycoprotein found on most cytotoxic T lymphocytes that mediates efficient cell to cell interactions within the immune system. The CD8 antigen, acting as a coreceptor, and the T cell receptor on the T lymphocyte recognize antigen displayed by an antigen presenting cell (APC) in the context of class I MHC molecules. The functional coreceptor is either a homodimer composed of two alpha chains, or a heterodimer composed of one alpha and one beta chain. Both alpha and beta chains share significant homology to immunoglobulin variable light chains. T cell activation through the antigen receptor (TCR) involves the cytoplasmic tails of the CD3 subunits: CD3 gamma, CD3 delta, CD3 epsilon and CD3 zeta. These CD3 subunits are structurally related members of the immunoglobulins super family encoded by closely linked genes on human chromosome 11. The CD3 components have long cytoplasmic tails that associate with cytoplasmic signal transduction molecules. This association is mediated at least in part by a double tyrosine based motif present in a single copy in the CD3 subunits. CD3 may play a role in TCR induced growth arrest, cell survival and proliferation. The CD3 antigen is present on 68-82% of normal peripheral blood lymphocytes, 65-85% of thymocytes and Purkinje cells in the cerebellum. It is never expressed on B or NK cells. Decreased percentages of T lymphocytes may be observed in some autoimmune diseases.
    • Cellular localizationMembrane; single pass type I membrane protein.
    • Alternative names
      • CD3D antibody
      • CD3d molecule antibody
      • CD3E antibody
      • CD3e molecule antibody
      • CD3G antibody
      • CD3g molecule antibody
      • CD8A antibody
      • CD8a molecule antibody
      • CD8B antibody
      • CD8b molecule antibody
      • Leu2 antibody
      see all

    References for Anti-CD3 + CD8 antibody [CA17.2A12 + YCATE 55.9] (Dual color: FITC + PE) (ab34266)

    ab34266 has not yet been referenced specifically in any publications.

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"