Overview

  • Product nameAnti-CD3 epsilon antibody [145-2C11] (Biotin)
    See all CD3 epsilon primary antibodies
  • Description
    Armenian Hamster monoclonal [145-2C11] to CD3 epsilon (Biotin)
  • ConjugationBiotin
  • Specificityab114039 is specific for a 25 kDa protein component (epsilon-T3) of the antigen specific T cell receptor in several Mouse strains. It reacts with all mature T cells and can both activate and inhibit T cell function.
  • Tested applicationsSuitable for: Flow Cytmore details
  • Species reactivity
    Reacts with: Mouse
  • Immunogen

    H-2Kb sp

  • Positive control
    • BALB/c Mouse thymocytes or splenic T Cells
  • General notes


    This monoclonal antibody, clone 145-2C11, was specifically designed to trigger T cell activation.

Properties

Applications

Our Abpromise guarantee covers the use of ab114039 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
Flow Cyt Use 1µg for 106 cells.

Target

  • FunctionThe CD3 complex mediates signal transduction.
  • Sequence similaritiesContains 1 Ig-like (immunoglobulin-like) domain.
    Contains 1 ITAM domain.
  • Cellular localizationMembrane.
  • Information by UniProt
  • Database links
  • Alternative names
    • CD3 epsilon antibody
    • CD3e antibody
    • CD3e antigen epsilon polypeptide (TiT3 complex) antibody
    • CD3E antigen epsilon polypeptide antibody
    • CD3E antigen, epsilon subunit antibody
    • CD3e molecule epsilon antibody
    • CD3e molecule, epsilon (CD3 TCR complex) antibody
    • CD3e molecule, epsilon (CD3-TCR complex) antibody
    • CD3E_HUMAN antibody
    • IMD18 antibody
    • T cell antigen receptor complex epsilon subunit of T3 antibody
    • T cell surface antigen T3/Leu 4 epsilon chain antibody
    • T cell surface glycoprotein CD3 epsilon chain antibody
    • T-cell surface antigen T3/Leu-4 epsilon chain antibody
    • T-cell surface glycoprotein CD3 epsilon chain antibody
    • T3E antibody
    • TCRE antibody
    see all

Anti-CD3 epsilon antibody [145-2C11] (Biotin) images

  • Flow cytometric analysis of CD3 epsilon in BALB/c thymocyte cells stained with ab114039 at 1 µg per 106 cells.
    Biotin Hamster IgG was used as isotypic control.
    Percentage of cells stained above control: 50.2%.
  • Flow Cytometric analysis of CD3 epsilon in BALB/c splenic T cells stained with ab114039 at 1 µg per 106 cells.
    Biotin Hamster IgG was used as isotypic control.
    Percentage of cells stained above control: 87.6%.

References for Anti-CD3 epsilon antibody [145-2C11] (Biotin) (ab114039)

This product has been referenced in:
  • Hirsch R  et al. Effects of in vivo administration of anti-T3 monoclonal antibody on T cell function in mice. I. Immunosuppression of transplantation responses. J Immunol 140:3766-72 (1988). Read more (PubMed: 3286764) »
  • Leo O  et al. Identification of a monoclonal antibody specific for a murine T3 polypeptide. Proc Natl Acad Sci U S A 84:1374-8 (1987). Read more (PubMed: 2950524) »

See all 2 Publications for this product

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"