Anti-CD320 antibody - C-terminal (ab171634)

Overview

  • Product name
    Anti-CD320 antibody - C-terminal
    See all CD320 primary antibodies
  • Description
    Rabbit polyclonal to CD320 - C-terminal
  • Tested applications
    Suitable for: WBmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Synthetic peptide within Human CD320 aa 152-182 (C terminal) conjugated to Keyhole Limpet Haemocyanin (KLH). The exact sequence is proprietary.
    Database link: Q9NPF0

  • Positive control
    • U251 cell line lysate

Properties

Applications

Our Abpromise guarantee covers the use of ab171634 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/100 - 1/500. Predicted molecular weight: 29 kDa.

Target

  • Function
    Germinal center-B (GC-B) cells differentiate into memory B-cells and plasma cells (PC) through interaction with T-cells and follicular dendritic cells (FDC). CD320 augments the proliferation of PC precursors generated by IL-10. Receptor for the cellular uptake of transcobalamin bound cobalamin.
  • Tissue specificity
    Expressed abundantly on follicular dendritic cells (FDCs).
  • Involvement in disease
    Defects in CD320 are the cause of methylmalonic aciduria type TCblR (MMATC) [MIM:613646]; also called methylmalonic aciduria due to transcobalamin receptor defect. MMATC is a metabolic disorder characterized by increased blood C3-acylcarnitine levels, elevated methylmalonate and homocysteine, and low uptake of transcobalamin-bound cobalamin, but normal conversion to adenosylcobalamin and methylcobalamin. Plasma vitamin B12 and total homocysteine are normal.
  • Sequence similarities
    Contains 2 LDL-receptor class A domains.
  • Cellular localization
    Membrane.
  • Information by UniProt
  • Database links
  • Alternative names
    • 8D6 antibody
    • 8D6 antigen antibody
    • 8D6A antibody
    • CD320 antibody
    • CD320 antigen antibody
    • CD320_HUMAN antibody
    • FDC-signaling molecule 8D6 antibody
    • FDC-SM-8D6 antibody
    • TCblR antibody
    • Transcobalamin receptor antibody
    see all

Images

  • Anti-CD320 antibody - C-terminal (ab171634) at 1/100 dilution + U251 cell line lysate at 35 µg
    Developed using the ECL technique

    Predicted band size : 29 kDa

References

ab171634 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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