Overview

  • Product name
  • Description
    Goat polyclonal to CD32B
  • Tested applications
    Suitable for: WB, IHC-P, ELISAmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Cynomolgus monkey
  • Immunogen

    Synthetic peptide:

    C-PDALEEPDDQNRI

    , corresponding to C terminal amino acids 298-310 of Human CD32B (UniProt ID: P31994).

  • Positive control
    • Human liver and placenta tissues; K562 lysate

Properties

Applications

Our Abpromise guarantee covers the use of ab110076 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 0.3 - 1 µg/ml. Predicted molecular weight: 34 kDa.
IHC-P Use a concentration of 3.75 µg/ml.
ELISA 1/16000.

Target

  • Function
    Receptor for the Fc region of complexed or aggregated immunoglobulins gamma. Low affinity receptor. Involved in a variety of effector and regulatory functions such as phagocytosis of immune complexes and modulation of antibody production by B-cells. Binding to this receptor results in down-modulation of previous state of cell activation triggered via antigen receptors on B-cells (BCR), T-cells (TCR) or via another Fc receptor. Isoform IIB1 fails to mediate endocytosis or phagocytosis. Isoform IIB2 does not trigger phagocytosis.
  • Tissue specificity
    Is the most broadly distributed Fc-gamma-receptor. Expressed in monocyte, neutrophils, macrophages, basophils, eosinophils, Langerhans cells, B-cells, platelets cells and placenta (endothelial cells). Not detected in natural killer cells.
  • Involvement in disease
    Note=A chromosomal aberration involving FCGR2B is found in a follicular lymphoma. Translocation t(1;22)(q22;q11). The translocation leads to the hyperexpression of the receptor. This may play a role in the tumor progression.
  • Sequence similarities
    Contains 2 Ig-like C2-type (immunoglobulin-like) domains.
  • Domain
    Contains 1 copy of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM). This motif is involved in modulation of cellular responses. The phosphorylated ITIM motif can bind the SH2 domain of several SH2-containing phosphatases.
  • Cellular localization
    Cell membrane.
  • Information by UniProt
  • Database links
  • Alternative names
    • CD32 antibody
    • CD32 antigen antibody
    • CD32B antibody
    • CDw32 antibody
    • Fc fragment of IgG, low affinity II, receptor for (CD32) antibody
    • Fc fragment of IgG, low affinity IIb, receptor antibody
    • Fc fragment of IgG, low affinity IIb, receptor (CD32) antibody
    • Fc fragment of IgG, low affinity IIb, receptor for (CD32) antibody
    • Fc fragment of IgG, low affinity IIb, receptor for antibody
    • Fc gamma receptor IIB antibody
    • Fc gamma RII antibody
    • Fc gamma RIIB antibody
    • Fc-gamma RII antibody
    • Fc-gamma RII-b antibody
    • Fc-gamma-RIIb antibody
    • FCG2 antibody
    • FCG2B_HUMAN antibody
    • Fcgr2 antibody
    • FCGR2B antibody
    • FCRII antibody
    • FcRII-b antibody
    • IGFR2 antibody
    • IgG Fc receptor II beta antibody
    • IgG Fc receptor II-b antibody
    • Low affinity immunoglobulin gamma Fc region receptor II antibody
    • Low affinity immunoglobulin gamma Fc region receptor II-b antibody
    • Ly-17 antibody
    • Lym 1 antibody
    • Lymphocyte antigen 17 antibody
    see all

Images

  • Anti-CD32B antibody (ab110076) at 0.3 µg/ml + K562 lysate (in RIPA buffer) at 35 µg
    Developed using the ECL technique

    Predicted band size : 34 kDa


    Exposure time : 1 hour
  • ab110076, at 3.75 µg/ml, staining CD32B in formalin fixed, paraffin embedded Human liver by Immunohistochemistry.
  • ab110076, at 3.75 µg/ml, staining CD32B in formalin fixed, paraffin embedded Human placenta by Immunohistochemistry.

References

ab110076 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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