Anti-CD34 antibody [4H11[APG]] (Biotin) (ab21893)

Overview

  • Product name
    Anti-CD34 antibody [4H11[APG]] (Biotin)
    See all CD34 primary antibodies
  • Description
    Mouse monoclonal [4H11[APG]] to CD34 (Biotin)
  • Conjugation
    Biotin
  • Specificity
    The antibody 4H11[APG] completely blocks binding of Class II antibody QBEnd10 and Class III antibodies BIRMA K3 and 8G12 on KG1a cell line.
  • Tested applications
    Suitable for: Flow Cytmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Tissue/ cell preparation: Permanent human cell line derived from peripheral leucocytes of a patient suffering from chronic myeloid leukaemia.

  • Epitope
    Class III epitope on CD34 antigen.
  • General notes

    The purified antibody is conjugated with Biotin-LC-NHS under optimum conditions. The reagent is free of unconjugated biotin.

Properties

Applications

Our Abpromise guarantee covers the use of ab21893 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
Flow Cyt 1/200. ab18434-Mouse monoclonal IgG1, is suitable for use as an isotype control with this antibody.

Target

  • Function
    Possible adhesion molecule with a role in early hematopoiesis by mediating the attachment of stem cells to the bone marrow extracellular matrix or directly to stromal cells. Could act as a scaffold for the attachment of lineage specific glycans, allowing stem cells to bind to lectins expressed by stromal cells or other marrow components. Presents carbohydrate ligands to selectins.
  • Tissue specificity
    Selectively expressed on hematopoietic progenitor cells and the small vessel endothelium of a variety of tissues.
  • Sequence similarities
    Belongs to the CD34 family.
  • Developmental stage
    On early hematopoietic progenitor cells.
  • Post-translational
    modifications
    Highly glycosylated.
    Phosphorylated on serine residues by PKC.
  • Cellular localization
    Membrane.
  • Information by UniProt
  • Database links
  • Alternative names
    • CD34 antibody
    • CD34 antigen antibody
    • CD34 molecule antibody
    • CD34_HUMAN antibody
    • Cluster designation 34 antibody
    • Hematopoietic progenitor cell antigen CD34 antibody
    • HPCA1 antibody
    • Mucosialin antibody
    • OTTHUMP00000034733 antibody
    • OTTHUMP00000034734 antibody
    see all

References for Anti-CD34 antibody [4H11[APG]] (Biotin) (ab21893)

ab21893 has not yet been referenced specifically in any publications.

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