Anti-CD38 antibody [90] (Phycoerythrin) (ab23308)

Overview

• Product name
  Anti-CD38 antibody [90] (Phycoerythrin)
  See all CD38 primary antibodies
• Description
  Rat monoclonal [90] to CD38 (Phycoerythrin)
• Conjugation
  Phycoerythrin. Ex: 488nm, Em: 575nm
• Specificity
  This antibody recognises the murine CD38 cell surface antigen, a 42-46kD glycoprotein expressed by B lymphocytes, a proportion of peripheral T lymphocytes and by peritoneal macrophages. In the mouse CD38 is expressed by follicular B cells, is down regulated on germinal centre B cells, and not expressed by mature plasma cells. This pattern of expression contrasts strikingly with that seen in the human.
• Tested applications
  Suitable for: Flow Cytmore details
• Species reactivity
  Reacts with: Mouse
  
• Immunogen

  Pre-B cells derived from IL-7 dependent bone marrow cultures. (Mouse).

• General notes

  Purified IgG conjugated to R. Phycoerythrin (RPE).

Properties

• Form
  Liquid
• Storage instructions
  Shipped at 4°C. Store at +4°C.
• Storage buffer
  Preservative: 0.09% Sodium Azide
  Constituents: 0.5% BSA, PBS
• Concentration information loading...
• Purity
  Protein A purified
• Clonality
  Monoclonal
• Clone number
  90
• Myeloma
  P3x63-Ag8.653
• Isotype
  IgG2a
• Research areas
  • Immunology
  • Adaptive Immunity
  • B Cells
  • CD

  • Stem Cells
  • Hematopoietic Progenitors
  • Hematopoietic Stem Cells
  • Human Lineage Negative

  • Stem Cells
  • Hematopoietic Progenitors
  • Surface Molecules

  • Stem Cells
  • Hematopoietic Progenitors
  • Lymphoid
  • B Lymphocytic Lineage

  • Stem Cells
  • Hematopoietic Progenitors
  • Lymphoid
  • T Lymphocytic Lineage

  • Stem Cells
  • Hematopoietic Progenitors
  • Lymphoid
  • NK Cell Lineage

  • Stem Cells
  • Hematopoietic Progenitors
  • Myeloid
  • Monocytic Lineage

  • Immunology
  • Adaptive Immunity
  • Regulatory T Cells

  • Cancer
  • Cancer Metabolism
  • Response to hypoxia

  • Metabolism
  • Pathways and Processes
  • Metabolism processes
  • Hypoxia

  • Metabolism
  • Types of disease
  • Cancer

Associated products

• Compatible Secondaries
  • Goat Anti-Rat IgG H&L (Alexa Fluor® 488) (ab150157)
  • Goat Anti-Rat IgG H&L (HRP) (ab205720)

Applications

Target

• Function
  Synthesizes cyclic ADP-ribose, a second messenger for glucose-induced insulin secretion. Also has cADPr hydrolase activity. Also moonlights as a receptor in cells of the immune system.
• Tissue specificity
  Expressed at high levels in pancreas, liver, kidney, brain, testis, ovary, placenta, malignant lymphoma and neuroblastoma.
• Sequence similarities
  Belongs to the ADP-ribosyl cyclase family.
• Developmental stage
  Preferentially expressed at both early and late stages of the B and T-cell maturation. It is also detected on erythroid and myeloid progenitors in bone marrow, where the level of surface expression was shown to decrease during differentiation of blast-forming unit E to colony-forming unit E.
• Cellular localization
  Membrane.

• Target information above from: UniProt accession P28907 The UniProt Consortium
  The Universal Protein Resource (UniProt) in 2010
  Nucleic Acids Res. 38:D142-D148 (2010) .

  Information by UniProt
• Database links
  • Entrez Gene: 12494 Mouse
  • SwissProt: P56528 Mouse
  • Unigene: 249873 Mouse
• Form
  There are 2 isoforms produced by alternative splicing.
• Alternative names
  • Acute lymphoblastic leukemia cells antigen CD38 antibody
  • ADP ribosyl cyclase 1 antibody
  • ADP ribosyl cyclase antibody

  • ADP ribosyl cyclase/cyclic ADP-ribose hydrolase antibody
  • ADP-ribosyl cyclase 1 antibody
  • ADPRC 1 antibody
  • ADPRC1 antibody
  • cADPr hydrolase 1 antibody
  • CD 38 antibody
  • CD38 antibody
  • CD38 antigen (p45) antibody
  • CD38 antigen antibody
  • CD38 molecule antibody
  • Cd38-rs1 antibody
  • CD38_HUMAN antibody
  • CD38H antibody
  • Cyclic ADP ribose hydrolase antibody
  • Cyclic ADP ribose hydrolase 1 antibody
  • Cyclic ADP-ribose hydrolase 1 antibody
  • EC 3.2.2.5 antibody
  • Ecto nicotinamide adenine dinucleotide glycohydrolase antibody
  • I-19 antibody
  • I19 (mouse) antibody
  • Lymphocyte differentiation antigen CD38 antibody
  • NAD(+) nucleosidase antibody
  • NIM-R5 antigen antibody
  • NIMR5 antigen (mouse) antibody
  • OTTHUMP00000158633 antibody
  • OTTHUMP00000217743 antibody
  • p45 antibody
  • T10 antibody

  see all

Protocols

• Flow cytometry protocols