Anti-CD38 antibody [90] (Phycoerythrin) (ab23308)
- Datasheet
- Specific References (1)
- Protocols
Overview
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Product nameAnti-CD38 antibody [90] (Phycoerythrin)
See all CD38 primary antibodies -
DescriptionRat monoclonal [90] to CD38 (Phycoerythrin)
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Host speciesRat
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ConjugationPhycoerythrin. Ex: 488nm, Em: 575nm
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SpecificityThis antibody recognises the murine CD38 cell surface antigen, a 42-46kD glycoprotein expressed by B lymphocytes, a proportion of peripheral T lymphocytes and by peritoneal macrophages. In the mouse CD38 is expressed by follicular B cells, is down regulated on germinal centre B cells, and not expressed by mature plasma cells. This pattern of expression contrasts strikingly with that seen in the human.
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Tested applicationsSuitable for: Flow Cytmore details
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Species reactivityReacts with: Mouse
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Immunogen
Pre-B cells derived from IL-7 dependent bone marrow cultures. (Mouse).
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General notes
Purified IgG conjugated to R. Phycoerythrin (RPE).
Properties
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FormLiquid
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Storage instructionsShipped at 4°C. Store at +4°C.
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Storage bufferPreservative: 0.09% Sodium Azide
Constituents: 0.5% BSA, PBS -
Concentration information loading... -
PurityProtein A purified
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ClonalityMonoclonal
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Clone number90
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MyelomaP3x63-Ag8.653
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IsotypeIgG2a
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Research areas
Associated products
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Alternative Versions
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Compatible Secondaries
Applications
Our Abpromise guarantee covers the use of ab23308 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
| Application | Abreviews | Notes |
|---|---|---|
| Flow Cyt |
Application notes
Flow Cyt: 1/Neat - 1/10 (Use 10µl for 106 cells)
Not tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.
Not tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.
Target
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FunctionSynthesizes cyclic ADP-ribose, a second messenger for glucose-induced insulin secretion. Also has cADPr hydrolase activity. Also moonlights as a receptor in cells of the immune system.
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Tissue specificityExpressed at high levels in pancreas, liver, kidney, brain, testis, ovary, placenta, malignant lymphoma and neuroblastoma.
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Sequence similaritiesBelongs to the ADP-ribosyl cyclase family.
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Developmental stagePreferentially expressed at both early and late stages of the B and T-cell maturation. It is also detected on erythroid and myeloid progenitors in bone marrow, where the level of surface expression was shown to decrease during differentiation of blast-forming unit E to colony-forming unit E.
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Cellular localizationMembrane.
- Information by UniProt
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Database links
- Entrez Gene: 12494 Mouse
- SwissProt: P56528 Mouse
- Unigene: 249873 Mouse
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FormThere are 2 isoforms produced by alternative splicing.
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Alternative names
- Acute lymphoblastic leukemia cells antigen CD38 antibody
- ADP ribosyl cyclase 1 antibody
- ADP ribosyl cyclase antibody
see all
Protocols
References
This product has been referenced in:
- Olme CH et al. Live cell detection of chromosome 2 deletion and Sfpi1/PU1 loss in radiation-induced mouse acute myeloid leukaemia. Leuk Res 37:1374-82 (2013). Flow Cyt ; Mouse . Read more (PubMed: 23806234) »
Customer reviews and Q&As
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"