The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Application notesFlow Cyt: Use 10µl of neat antibody to label 106 cells or 100µl of whole blood.
Not yet tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.
FunctionIn the nervous system, could hydrolyze ATP and other nucleotides to regulate purinergic neurotransmission. Could also be implicated in the prevention of platelet aggregation. Hydrolyzes ATP and ADP equally well.
Tissue specificityExpressed primarily on activated lymphoid cells. Also expressed in endothelial tissues. The vascular isoform and the placental isoform II are present in both placenta and umbilical vein, whereas placental isoform I is present in placenta only.
Sequence similaritiesBelongs to the GDA1/CD39 NTPase family.
Post-translational modificationsThe N-terminus is blocked. Palmitoylated in the N-terminal part.
Staining of human peripheral blood lymphocytes using ab30423.
References for Anti-CD39 antibody [A1] (FITC) (ab30423)
This product has been referenced in:
Clark RA et al. Human squamous cell carcinomas evade the immune response by down-regulation of vascular E-selectin and recruitment of regulatory T cells. J Exp Med205:2221-34 (2008).
Read more (PubMed: 18794336) »
Aversa GG et al. Detection of a late lymphocyte activation marker by A1, a new monoclonal antibody. Transplant Proc20:49-52 (1988).
Read more (PubMed: 2830689) »