The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Use 10µl for 106 cells.
Use 10µl to label 106 cells or 100µl whole blood.
ab91357-Mouse monoclonal IgG1, is suitable for use as an isotype control with this antibody.
FunctionIn the nervous system, could hydrolyze ATP and other nucleotides to regulate purinergic neurotransmission. Could also be implicated in the prevention of platelet aggregation. Hydrolyzes ATP and ADP equally well.
Tissue specificityExpressed primarily on activated lymphoid cells. Also expressed in endothelial tissues. The vascular isoform and the placental isoform II are present in both placenta and umbilical vein, whereas placental isoform I is present in placenta only.
Sequence similaritiesBelongs to the GDA1/CD39 NTPase family.
Post-translational modificationsThe N-terminus is blocked. Palmitoylated in the N-terminal part.
References for Anti-CD39 antibody [A1] (Phycoerythrin) (ab30424)
This product has been referenced in:
Jandus C et al. Increased numbers of circulating polyfunctional Th17 memory cells in patients with seronegative spondylarthritides. Arthritis Rheum58:2307-17 (2008).
Read more (PubMed: 18668556) »
Valencic E et al. T cells stimulated in vitro have a suppressive function but do not contain only regulatory T cells. Clin Exp Immunol150:561-6 (2007).
Read more (PubMed: 17900303) »