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Mouse monoclonal [74-12-4] to CD4 (FITC)
FITC. Ex: 493nm, Em: 528nm
ab24989 recognises porcine CD4a.
The details of the immunogen for this antibody are not available.
Abpromise guarantee covers the use of
in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Use at an assay dependent concentration. Cytotoxicity assays.
Use 1µg for 10
6 cells. ab18427-Mouse monoclonal IgG2b, is suitable for use as an isotype control with this antibody.
Use at an assay dependent concentration.
Accessory protein for MHC class-II antigen/T-cell receptor interaction. May regulate T-cell activation. Induces the aggregation of lipid rafts.
Contains 3 Ig-like C2-type (immunoglobulin-like) domains.
Contains 1 Ig-like V-type (immunoglobulin-like) domain.
Palmitoylation and association with LCK contribute to the enrichment of CD4 in lipid rafts.
Cell membrane. Localizes to lipid rafts. Removed from plasma membrane by HIV-1 Nef protein that increases clathrin-dependent endocytosis of this antigen to target it to lysosomal degradation. Cell surface expression is also down-modulated by HIV-1 Envelope polyprotein gp160 that interacts with, and sequesters CD4 in the endoplasmic reticulum.
Information by UniProt
CD 4 antibody
CD4 (L3T4) antibody
References for Anti-CD4 antibody [74-12-4] (FITC) (ab24989)
has not yet been referenced specifically in any publications.
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"