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Storage instructions Shipped at 4°C. Store at +4°C short term (1-2 weeks). Store at +4°C. It is important to note that this product is reported to be light sensitive.
Storage buffer pH: 7.20 Preservative: 0.09% Sodium azide Constituents: 0.142% Dibasic monohydrogen sodium phosphate, 0.87% Sodium chloride, 0.1% Gelatin
Concentration information loading...
Purity Affinity purified
Primary antibody notes This antibody blocks helper T cell responses to MHC class II antigens,including cytolysis, proliferation, allogeneic B cell help, and release of lymphokines.
Clone number GK1.5
Light chain type kappa
Abpromise guarantee covers the use of
in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Use at an assay dependent concentration.
Function Accessory protein for MHC class-II antigen/T-cell receptor interaction. May regulate T-cell activation. Induces the aggregation of lipid rafts.
Sequence similarities Contains 3 Ig-like C2-type (immunoglobulin-like) domains. Contains 1 Ig-like V-type (immunoglobulin-like) domain.
Post-translational modifications Palmitoylation and association with LCK contribute to the enrichment of CD4 in lipid rafts.
Cellular localization Cell membrane. Localizes to lipid rafts. Removed from plasma membrane by HIV-1 Nef protein that increases clathrin-dependent endocytosis of this antigen to target it to lysosomal degradation. Cell surface expression is also down-modulated by HIV-1 Envelope polyprotein gp160 that interacts with, and sequesters CD4 in the endoplasmic reticulum.
Information by UniProt
CD 4 antibody
CD4 (L3T4) antibody
References for Anti-CD4 antibody [GK1.5] (Allophycocyanin) (ab25497)
has not yet been referenced specifically in any publications.
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"