Post-translational modificationsPalmitoylation and association with LCK contribute to the enrichment of CD4 in lipid rafts.
Cellular localizationCell membrane. Localizes to lipid rafts. Removed from plasma membrane by HIV-1 Nef protein that increases clathrin-dependent endocytosis of this antigen to target it to lysosomal degradation. Cell surface expression is also down-modulated by HIV-1 Envelope polyprotein gp160 that interacts with, and sequesters CD4 in the endoplasmic reticulum.
Flow analysis of CD4 in mouse splenocytes using 0.1 µg of ab86858 for 106 cells. Shaded histogram represents cells without antibody; green represents isotype control; red represents anti CD4 antibody (ab86858).
References for Anti-CD4 antibody [GK1.5] (FITC) (ab86858)
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