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Storage instructions Shipped at 4°C. Store at +4°C.
Storage buffer Preservative: 0.09% Sodium Azide
Constituents: 1% BSA, PBS, pH 7.4
Concentration information loading...
Primary antibody notes This antibody inhibits proliferation and IL2 production in the MLR reaction.
Clone number W3/25
Abpromise guarantee covers the use of
in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
1/1 - 1/10.
Use 10µl of the suggested working dilution to label 10
6 cells in 100µl. ab91357-Mouse monoclonal IgG1, is suitable for use as an isotype control with this antibody.
Function Accessory protein for MHC class-II antigen/T-cell receptor interaction. May regulate T-cell activation. Induces the aggregation of lipid rafts.
Sequence similarities Contains 3 Ig-like C2-type (immunoglobulin-like) domains. Contains 1 Ig-like V-type (immunoglobulin-like) domain.
Post-translational modifications Palmitoylation and association with LCK contribute to the enrichment of CD4 in lipid rafts.
Cellular localization Cell membrane. Localizes to lipid rafts. Removed from plasma membrane by HIV-1 Nef protein that increases clathrin-dependent endocytosis of this antigen to target it to lysosomal degradation. Cell surface expression is also down-modulated by HIV-1 Envelope polyprotein gp160 that interacts with, and sequesters CD4 in the endoplasmic reticulum.
Information by UniProt
CD 4 antibody
CD4 (L3T4) antibody
References for Anti-CD4 antibody [W3/25] (Phycoerythrin) (ab33783)
has not yet been referenced specifically in any publications.
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"