• Product nameAnti-CD40 antibody [MAB89]
    See all CD40 primary antibodies
  • Description
    Mouse monoclonal [MAB89] to CD40
  • Tested applicationsSuitable for: Flow Cyt, Functional Studies, Celluar Activationmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Anti-mu activated tonsillar human B cells.



Our Abpromise guarantee covers the use of ab19684 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
Flow Cyt
Functional Studies
Celluar Activation
  • Application notesCellular activation: Use at a concentration of 10 ng/ml.
    Flow Cyt: Use 2µg for 5X105 cells.
    FuncS: Use at an assay dependent dilution.

    Not tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • Target

    • FunctionReceptor for TNFSF5/CD40LG.
    • Tissue specificityB-cells and in primary carcinomas.
    • Involvement in diseaseDefects in CD40 are the cause of hyper-IgM immunodeficiency syndrome type 3 (HIGM3) [MIM:606843]; also known as hyper-IgM syndrome 3. HIGM3 is an autosomal recessive disorder which includes an inability of B cells to undergo isotype switching, one of the final differentiation steps in the humoral immune system, an inability to mount an antibody-specific immune response, and a lack of germinal center formation.
    • Sequence similaritiesContains 4 TNFR-Cys repeats.
    • Cellular localizationSecreted and Cell membrane.
    • Information by UniProt
    • Database links
    • Alternative names
      • AI326936 antibody
      • B cell associated molecule CD40 antibody
      • B cell surface antigen CD40 antibody
      • B cell-associated molecule antibody
      • B-cell surface antigen CD40 antibody
      • Bp50 antibody
      • CD 40 antibody
      • CD40 antibody
      • CD40 antigen (TNF receptor superfamily member 5) antibody
      • CD40 antigen antibody
      • CD40 molecule antibody
      • CD40 molecule, TNF receptor superfamily member 5 antibody
      • CD40 protein antibody
      • CD40 type II isoform antibody
      • CD40L receptor antibody
      • CDw40 antibody
      • GP39 antibody
      • HIGM1 antibody
      • IGM antibody
      • IMD3 antibody
      • MGC9013 antibody
      • Nerve growth factor receptor related B lymphocyte activation molecule antibody
      • OTTHUMP00000031699 antibody
      • OTTHUMP00000031700 antibody
      • p50 antibody
      • T-BAM antibody
      • TBAM antibody
      • TNF receptor superfamily member 5 antibody
      • TNFRSF5 antibody
      • TNR5_HUMAN antibody
      • TRAP antibody
      • Tumor necrosis factor receptor superfamily , member 5 antibody
      • Tumor necrosis factor receptor superfamily member 5 antibody
      • Tumor necrosis factor receptor superfamily member 5 precursor antibody
      • Tumor necrosis factor receptor superfamily, member 5, isoform CRA_a antibody
      see all

    References for Anti-CD40 antibody [MAB89] (ab19684)

    This product has been referenced in:
    • Ornatsky O  et al. Highly multiparametric analysis by mass cytometry. J Immunol Methods 361:1-20 (2010). Flow Cyt ; Human . Read more (PubMed: 20655312) »
    • Rousset F  et al. Interleukin 10 is a potent growth and differentiation factor for activated human B lymphocytes. Proc Natl Acad Sci U S A 89:1890-3 (1992). Read more (PubMed: 1371884) »

    See all 2 Publications for this product

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    Thank you for contacting us.

    I can confirm that the product was sterile when we dispatched it to you. It is fully guaranteed and is suitable for use in Flow Cyt, Functional Studies, Cellular activation.

    I hope this information is ...

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    Thank you for your enquiry. The "activation" information came from the following published reference. The paper discusses activation of B cells. http://www.pubmedcentral.nih.gov/picrender.fcgi?artid=48559&blobtype=pdf I have also added a link...

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    Thank you for your enquiry. Mouse monoclonal [MAB89] to CD40 (ab19684) was characterized as part of the Leucocyte Workshop VI. Testing was done by IHC (frozen sections), Western blot, and functional studies. There are several published referenc...

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