Anti-CD41 antibody [MEM-06] (FITC) (ab21851)

Overview

  • Product nameAnti-CD41 antibody [MEM-06] (FITC)See all CD41 primary antibodies ...
  • Description
    Mouse monoclonal [MEM-06] to CD41 (FITC)
  • ConjugationFITC. Ex: 493nm, Em: 528nm
  • Conjugation notesThe purified antibody is conjugated with Fluorescein isothiocyanate (FITC) under optimum conditions. The reagent is free of unconjugated FITC and adjusted for direct use. No reconstitution is necessary.
  • Tested applicationsFlow Cytmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Tissue/ cell preparation (Human). (Leucocytes of patient suffering from LGL-type leukaemia).

Properties

Applications

Our Abpromise guarantee covers the use of ab21851 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
Flow Cyt
  • Application notesFlow Cyt: Use 20µl of antibody per 100µl whole blood.

    Not tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • Target

    • FunctionIntegrin alpha-IIb/beta-3 is a receptor for fibronectin, fibrinogen, plasminogen, prothrombin, thrombospondin and vitronectin. It recognizes the sequence R-G-D in a wide array of ligands. It recognizes the sequence H-H-L-G-G-G-A-K-Q-A-G-D-V in fibrinogen gamma chain. Following activation integrin alpha-IIb/beta-3 brings about platelet/platelet interaction through binding of soluble fibrinogen. This step leads to rapid platelet aggregation which physically plugs ruptured endothelial cell surface.
    • Tissue specificityIsoform 1 and isoform 2 were identified in platelets and megakaryocytes, but not in reticulocytes or in Jurkat and U937 white blood cell line. Isoform 3 is expressed by leukemia, prostate adenocarcinoma and melanoma cells but not by platelets or normal prostate or breast epithelial cells.
    • Involvement in diseaseDefects in ITGA2B are a cause of Glanzmann thrombasthenia (GT) [MIM:273800]; also known as thrombasthenia of Glanzmann and Naegeli. GT is the most common inherited disease of platelets. It is an autosomal recessive disorder characterized by mucocutaneous bleeding of mild-to-moderate severity and the inability of this integrin to recognize macromolecular or synthetic peptide ligands. GT has been classified clinically into types I and II. In type I, platelets show absence of the glycoprotein IIb/beta-3 complexes at their surface and lack fibrinogen and clot retraction capability. In type II, the platelets express the glycoprotein IIb/beta-3 complex at reduced levels (5-20% controls), have detectable amounts of fibrinogen, and have low or moderate clot retraction capability. The platelets of GT 'variants' have normal or near normal (60-100%) expression of dysfunctional receptors.
    • Sequence similaritiesBelongs to the integrin alpha chain family.
      Contains 7 FG-GAP repeats.
    • Cellular localizationMembrane.
    • Information by UniProt
    • Database links
    • Alternative names
      • antigen CD41 antibody
      • BDPLT16 antibody
      • BDPLT2 antibody
      • CD41 antibody
      • cd41 antigen antibody
      • CD41a antibody
      • cd41b antibody
      • form 2 antibody
      • gp2b antibody
      • GPalpha IIb antibody
      • gpalphaiib antibody
      • gpiib antibody
      • GT antibody
      • gta antibody
      • HPA3 antibody
      • Integrin alpha 2b antibody
      • Integrin alpha IIb antibody
      • Integrin alpha-IIb light chain antibody
      • Integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41) antibody
      • ITA2B_HUMAN antibody
      • ITGA2B antibody
      • ITGAB antibody
      • platelet fibrinogen receptor alpha antibody
      • platelet fibrinogen receptor, alpha subunit antibody
      • platelet glycoprotein IIb of IIb/IIIa complex antibody
      • platelet membrane glycoprotein iib antibody
      • platelet specific antigen bak antibody
      see all

    References for Anti-CD41 antibody [MEM-06] (FITC) (ab21851)

    ab21851 has not yet been referenced specifically in any publications.

    Product Wall

    There are currently no Abreviews or Questions for ab21851.
    Please use the links above to contact us or submit feedback about this product.

    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"