Anti-CD42a antibody [GR-P] (OC515) (ab119492)

Overview

  • Product name
    Anti-CD42a antibody [GR-P] (OC515)
    See all CD42a primary antibodies
  • Description
    Mouse monoclonal [GR-P] to CD42a (OC515)
  • Conjugation
    OC515. Ex: 405nm, Em: 515nm
  • Tested applications
    Suitable for: Flow Cytmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Human red blood cells and platelets

  • Positive control
    • Human platelets from normal peripheral blood.
  • General notes

    OC515 (Abs/Em Max:405/518nm). Direct replacement for Pacific Orange®.

Properties

  • Form
    Liquid
  • Storage instructions
    Shipped at 4°C. Store at +4°C.
  • Storage buffer
    pH: 7.20
    Preservative: 0.09% Sodium azide
    Note: Buffer containing antibody stabilizer solution.
  • Concentration information loading...
  • Purity
    Immunogen affinity purified
  • Clonality
    Monoclonal
  • Clone number
    GR-P
  • Isotype
    IgG2a
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab119492 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
Flow Cyt Use 5µl for 106 cells. ab126028-Mouse monoclonal IgG2a, is suitable for use as an isotype control with this antibody.

Target

  • Function
    The GPIb-V-IX complex functions as the vWF receptor and mediates vWF-dependent platelet adhesion to blood vessels. The adhesion of platelets to injured vascular surfaces in the arterial circulation is a critical initiating event in hemostasis. GP-IX may provide for membrane insertion and orientation of GP-Ib.
  • Involvement in disease
    Defects in GP9 are a cause of Bernard-Soulier syndrome (BSS) [MIM:231200]; also known as giant platelet disease (GPD). BSS patients have unusually large platelets and have a clinical bleeding tendency.
  • Sequence similarities
    Contains 1 LRR (leucine-rich) repeat.
    Contains 1 LRRCT domain.
    Contains 1 LRRNT domain.
  • Cellular localization
    Membrane.
  • Information by UniProt
  • Database links
  • Alternative names
    • CD42a antibody
    • Glycoprotein 9 antibody
    • Glycoprotein IX antibody
    • Glycoprotein IX (platelet) antibody
    • Glycoprotein IX precursor antibody
    • GP IX antibody
    • GP-IX antibody
    • GP9 antibody
    • GPIX antibody
    • GPIX_HUMAN antibody
    • Platelet glycoprotein IX antibody
    see all

Images

  • ab119492, at 5 µl/106 cells, staining CD42a in Human platelets in normal peripheral blood cells by Flow Cytometry. Total events were used for the analysis.

References

ab119492 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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