Overview

  • Product name
    Anti-CD44v3 antibody [VFF-327]
  • Description
    Mouse monoclonal [VFF-327] to CD44v3
  • Specificity
    This antibody specifically recognises an epitope encoded by exon V3 on the variant portion of human CD44
  • Tested applications
    Suitable for: Flow Cyt, IHC-Fr, IHC-Pmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    The details of the immunogen for this antibody are not available.

Properties

  • Form
    Liquid
  • Storage instructions
    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term.
  • Storage buffer
    Preservative: 0.09% Sodium Azide
    Constituents: PBS
  • Concentration information loading...
  • Purity
    IgG fraction
  • Clonality
    Monoclonal
  • Clone number
    VFF-327
  • Isotype
    IgG1
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab34229 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
Flow Cyt
IHC-Fr
IHC-P
  • Application notes
    Flow Cyt: Use 10µl (at a concentration of 10 µg/ml) for 106 cells in 100µl.
    IHC-Fr: Use at a concentration of 10 µg/ml.
    IHC-P: Use at a concentration of 10 µg/ml. Antigen retrieval using heat treatment prior to staining of paraffin sections.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • Target

    • Relevance
      Receptor for hyaluronic acid (HA). Mediates cell-cell and cell-matrix interactions through its affinity for HA, and possibly also through its affinity for other ligands such as osteopontin, collagens, and matrix metalloproteinases (MMPs). Adhesion with HA plays an important role in cell migration, tumor growth and progression. Also involved in lymphocyte activation, recirculation and homing, and in hematopoiesis. Altered expression or dysfunction causes numerous pathogenic phenotypes. Great protein heterogeneity due to numerous alternative splicing and post-translational modification events. There are 17 different isoforms.
    • Cellular localization
      Membrane; single-pass type I membrane protein
    • Database links
    • Alternative names
      • CD44 antigen antibody
      • CD44 molecule antibody
      • Heparan sulfate proteoglycan antibody
      • IN antibody
      • MUTCH 1 antibody
      • Phagocytic glycoprotein I antibody
      see all

    References

    This product has been referenced in:
    • Alam TN  et al. Differential expression of CD44 during human prostate epithelial cell differentiation. J Histochem Cytochem 52:1083-90 (2004). Read more (PubMed: 15258184) »
    • Seiter S  et al. Mitigation of delayed-type hypersensitivity reactions by a CD44 variant isoform v3-specific antibody: blockade of leukocyte egress. J Invest Dermatol 113:11-21 (1999). Read more (PubMed: 10417612) »

    See all 2 Publications for this product

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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