Anti-CD45RC antibody [IBL-8] (ab3135)

Overview

  • Product nameAnti-CD45RC antibody [IBL-8]
    See all CD45RC primary antibodies
  • Description
    Rat monoclonal [IBL-8] to CD45RC
  • SpecificityThis antibody recognises the exon C-dependent RC isoform of CD45. It reacts strongly with B cells and less intensely with most CD8+ T cells. It does not recognise CD4+ T cells.
  • Tested applicationsSuitable for: Flow Cyt, IHC-Fr, IPmore details
  • Species reactivity
    Reacts with: Mouse
  • Immunogen

    Mouse spleen cells.

Properties

Applications

Our Abpromise guarantee covers the use of ab3135 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
Flow Cyt
IHC-Fr
IP
  • Application notesRecommended range of antibody concentration is 1 - 10 µg/ml.
    Not tested in applications other than those listed above.

    Optimal dilutions / concentrations should be determined by the end user.
  • Target

    • RelevanceThe CD45 family of cell surface glycoprotein antigens exist as a set of isoforms. The patterns of monoclonal antibody recognition of the CD45 phenotypes can be restricted (CD45RA, RB and RC), or broader, such as the CD45 T 200 species. The "restricted" subsets of this group arise as a result of translation of alternatively spliced mRNAs from exons A, B and C (exons 4, 5 and 6), where exons 3-15 encode the extracellular domain of the CD45 molecule. The restricted epitopes are differentially expressed on T and B lymphocytes, including functionally distinct T cells. CD45 (LCA) is a transmembrane phosphotyrosine phosphatase expressed on leucocytes. Myeloid cells do not express the RC isoform.
    • Cellular localizationMembrane; Single-pass type I membrane protein. Membrane raft. Note: Colocalized with DPP4 in membrane rafts.
    • Database links
    • Alternative names
      • B220 antibody
      • CD45 antibody
      • CD45R antibody
      • EC 3.1.3.48 antibody
      • GP180 antibody
      • L-CA antibody
      • LCA antibody
      • Leukocyte common antigen antibody
      • loc antibody
      • Ly-5 antibody
      • LY5 antibody
      • Ly5, homolog of antibody
      • Lymphocyte antigen 5 antibody
      • Lyt-4 antibody
      • Protein tyrosine phosphatase receptor type C antibody
      • PTPRC antibody
      • Receptor-type tyrosine-protein phosphatase C antibody
      • RT7 antibody
      • T200 antibody
      • T200 Glycoprotein antibody
      see all

    References for Anti-CD45RC antibody [IBL-8] (ab3135)

    ab3135 has not yet been referenced specifically in any publications.

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